# US 9,040,502 B2 · Anti-XDR-TB drug, anti-MDR-TB drug, and combination anti-tuberculosis drug

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- Number: US 9,040,502 B2
- Document ID: US9040502B2
- Status: Granted
- Kind: B2
- Application number: 13/075,356
- Filed: 2011-03-30
- Published: 2011-09-29
- Granted: 2015-05-26
- Earliest claimed: 2008-10-02
- Assignees: Microbial Chemistry Research Foundation; Infectious Disease Research Institute
- Applicants: Yoshiaki Takahashi; Masayuki Igarashi; Masaji Okada
- Inventors: Yoshiaki Takahashi; Masayuki Igarashi; Masaji Okada
- Web page: https://patentgrep.com/patent/US9040502B2

## CPC

- C07H 19/067: with ribosyl as the saccharide radical
- A61K 31/4409: only substituted in position 4, e.g. isoniazid, iproniazid
- A61K 31/496: Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
- A61K 31/7072: having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
- A61P 31/04: Antibacterial agents
- A61P 31/06: for tuberculosis
- A61P 43/00: Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C07H: SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS (derivatives of aldonic or saccharic acids C07C, C07D; aldonic acids, saccharic acids C07C59/105, C07C59/285; cyanohydrins C07C255/16; glycals C07D; compounds of unknown constitution C07G; polysaccharides, derivatives thereof C08B; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification C12N15/00; sugar industry C13)
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

A method for treating an individual infected with XDR-TB, the method including administering to the individual an anti-XDR-TB drug which comprises a compound having a structure expressed by Structural Formula (1) below:

## Claims

### Claim 1

A method for treating an individual infected with extensively drug-resistant tuberculosis, the method comprising:
administering to the individual an anti-extensively drug-resistant tuberculosis drug which comprises a compound having a structure expressed by Structural Formula (1) below:

### Claim 2

A method for treating an individual infected with multidrug-resistant tuberculosis, the method comprising:
administering to the individual an anti-multidrug-resistant tuberculosis drug which comprises a compound having a structure expressed by Structural Formula (1) below:

### Claim 3

A method for treating an individual infected with drug-sensitive tuberculosis bacteria, the method comprising:
administering to the individual a drug, wherein the drug comprises (i) compound having a structure expressed by Structural Formula (1) below:
and (ii) at least one anti-tuberculosis drug selected from rifampicin (RFP) and isonicotinic acid hydrazide (INH).