# US 9,040,476 B2 · Skin cleanser composition > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 9,040,476 B2 - Document ID: US9040476B2 - Status: Granted - Kind: B2 - Application number: 13/976,716 - Filed: 2011-12-27 - Published: 2013-11-07 - Granted: 2015-05-26 - Earliest claimed: 2010-12-28 - Assignees: Kao Corporation - Applicants: Ryosuke Fujii; Yasuhiro Doi; Masanori Takai; Hiromoto Mizushima; Rie Tanaka - Inventors: Ryosuke Fujii; Yasuhiro Doi; Masanori Takai; Hiromoto Mizushima; Rie Tanaka - Web page: https://patentgrep.com/patent/US9040476B2 ## CPC - A61K 8/731: {Cellulose; Quaternized cellulose derivatives} - A61Q 19/10: Washing or bathing preparations - C08B 11/193: Mixed ethers, i.e. ethers with two or more different etherifying groups - A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D) - A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS - C08B: POLYSACCHARIDES; DERIVATIVES THEREOF (polysaccharides containing less than six saccharide radicals attached to each other by glycosidic linkages C07H; fermentation or enzyme-using processes C12P19/00; sugar industry C13; production of cellulose D21) ## Abstract The present invention relates to a skin cleanser composition capable of providing an excellent frictional resistance feeling during rinsing and capable of giving an excellent silky feeling with moisturization to the skin after drying, and to a method for producing the composition. The skin cleanser composition contains a cat ionized hydroxypropyl cellulose (A) and a surfactant (B), and the cationized hydroxypropyl cellulose (A) has an anhydroglucose-derived main chain, and has a degree of substitution with cationized ethyleneoxy group of from 0.01 to 3.0 and a degree of substitution with propyleneoxy group of from 0.01 to 2.9. ## Claims ### Claim 1 A skin cleanser composition comprising a cationized hydroxypropyl cellulose (A) and a surfactant (B), wherein the cationized hydroxypropyl cellulose (A) has an anhydroglucose-derived main chain represented by the following general formula (1), and has a degree of substitution with cationized ethyleneoxy group of from 0.01 to 3.0 and a degree of substitution with propyleneoxy group of from 0.01 to 2.9: wherein R1, R2 and R3 each independently represent a substituent having a cationized ethyleneoxy group and a propyleneoxy group represented by the following general formula (2); n indicates a mean degree of polymerization of anhydroglucose and is a number of from 20 to 5000, wherein one of Y1 and Y2 is a hydrogen atom and the other is a cationic group represented by the following general formula (3); PO represents a propyleneoxy group; p indicates the number of cationized ethyleneoxy groups (—CH(Y1)—CH(Y2)—O—) in the general formula (2) and q indicates the number of propyleneoxy groups (—PO—) therein, each being 0 or a positive integer; in case where both of p and q are not 0, the addition sequence of the cationized ethyleneoxy group and the propyleneoxy group is not defined, and in case where p and/or q are/is 2 or more, a binding form may be a block co-polymer or a random co-polymer; wherein R4, R5 and R6 each independently represent a linear or branched alkyl group having from 1 to 3 carbon atoms, and X− represents an anionic group. ### Claim 2 (depends on 1) The skin cleanser composition according to claim 1, wherein the content of the cationized hydroxypropyl cellulose (A) is from 0.005 to 10% by mass. ### Claim 3 (depends on 1) The skin cleanser composition according to claim 1, wherein the mean degree of polymerization, n, of the anhydroglucose in the general formula (1) is from 100 to 500. ### Claim 4 (depends on 1) The skin cleanser composition according to claim 1, wherein the ratio of the cationized hydroxypropyl cellulose (A) to the surfactant (B) in the skin cleanser composition is, as a ratio by mass of [cationized hydroxypropyl cellulose/surfactant], from 0.0001 to 1. ### Claim 5 (depends on 1) The skin cleanser composition according to claim 1, wherein the cationized hydroxypropyl cellulose (A) is obtained by the following steps (a-1) to (a-3): Step (a-1): a step of adding a cationizing agent to a cellulose-containing raw material and processing it with a grinder, Step (a-2): a step of adding a base to the grinder-processed product obtained in the step (a-1), and while processing it with a grinder, reacting the cellulose-containing raw material and the cationizing agent to give a cationized cellulose, Step (a-3): a step of reacting the cationized cellulose obtained in the step (a-2) with propylene oxide to give the cationized hydroxypropyl cellulose (A). ### Claim 6 (depends on 1) The skin cleanser composition according to claim 1, wherein the cationized hydroxypropyl cellulose (A) is obtained by the following steps (b-1) to (b-4): Step (b-1): a step of processing a cellulose-containing raw material with a grinder to give a cellulose-containing raw material that comprises a cellulose having a degree of crystallinity of from 10 to 50%, Step (b-2): a step of adding to the cellulose-containing raw material obtained in the step (b-1), a base in an amount of from 0.6 to 1.5 molar times per mol of the anhydroglucose unit that constitutes the cellulose, and water in an amount of from 20 to 100% by mass relative to the cellulose in the cellulose-containing raw material, thereby giving an alkali cellulose, Step (b-3): a step of reacting the alkali cellulose obtained in the step (b-2) with propylene oxide to give a hydroxypropyl cellulose, Step (b-4): a step of reacting the hydroxypropyl cellulose obtained in the step (b-3) with a cationizing agent to give the cationized hydroxypropyl cellulose (A). ### Claim 7 (depends on 1) The skin cleanser composition according to claim 1, wherein the cationized hydroxypropyl cellulose (A) is obtained by the following steps (c-1) to (c-4): Step (c-1): a step of processing a mixture of a cellulose-containing raw material and a base in an amount of from 0.6 to 1.5 molar times per mol of the anhydroglucose unit that constitutes the cellulose in the cellulose-containing raw material, with a grinder under the condition where the water content in the cellulose-containing raw material is at most 10% by weight relative to the cellulose therein, thereby giving a ground cellulose/base mixture in which the mean particle size of the cellulose is from 10 to 150 μm, Step (c-2): a step of adding water to the ground cellulose/base mixture obtained in the step (c-1) to thereby control the water content in the ground cellulose/base mixture to be from 30 to 100% by mass relative to the cellulose in the cellulose-containing raw material used in the step (c-1), thereby giving an alkali cellulose, Step (c-3): a step of reacting the alkali cellulose obtained in the step (c-2) with propylene oxide to give a hydroxypropyl cellulose, Step (c-4): a step of reacting the hydroxypropyl cellulose obtained in the step (c-3) with a cationizing agent to give the cationized hydroxypropyl cellulose (A). ### Claim 8 (depends on 1) The skin cleanser composition according to claim 1, which further comprises an oil (C). ### Claim 9 (depends on 8) The skin cleanser composition according to claim 8, wherein the content of the oil (C) is from 1 to 40% by mass. ### Claim 10 (depends on 8) The skin cleanser composition according to claim 8, wherein the ratio by mass of the oil (C) to the cationized hydroxypropyl cellulose (A) [oil (C)/cationized hydroxypropyl cellulose (A)] is from 1 to 400.