# US 9,040,102 B2 · Composition comprising longan arillus extract or combined extract comprising the same for treating neurodegenerative disease

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- Number: US 9,040,102 B2
- Document ID: US9040102B2
- Status: Granted
- Kind: B2
- Application number: 13/031,751
- Filed: 2011-02-22
- Published: 2011-12-29
- Granted: 2015-05-26
- Earliest claimed: 2010-06-24
- Assignees: Korea Institute of Science and Technology
- Applicants: Hyun-Ok Yang; Na-Young Bae; Hak-Cheol Kwon; Sung-Kwon Chung; Myung-Sook Oh
- Inventors: Hyun-Ok Yang; Na-Young Bae; Hak-Cheol Kwon; Sung-Kwon Chung; Myung-Sook Oh
- Web page: https://patentgrep.com/patent/US9040102B2

## CPC

- A61K 36/77: Sapindaceae (Soapberry family), e.g. lychee or soapberry
- A61K 36/31: Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
- A61K 36/488: Pueraria (kudzu)
- A61K 36/539: Scutellaria (skullcap)
- A61P 21/00: Drugs for disorders of the muscular or neuromuscular system
- A61P 25/00: Drugs for disorders of the nervous system
- A61P 25/16: Anti-Parkinson drugs
- A61P 25/28: for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

This disclosure relates to a composition for prevention or treatment of neurodegenerative disease comprising longan arillus extract, or combined extract comprising longan arillus. The composition exhibits remarkably excellent prevention or treatment effect of neurodegenerative disease by containing longan arillus extract or combined extract comprising longan arillus, and particularly, it may effectively prevent or treat neurodegenerative disease by significantly protecting dopaminergic neurons from neurotoxicity due to MPTP selectively acting on dopaminergic nervous system and neurotoxicity due to aggregation of alpha-synuclein proteins.

## Claims

### Claim 1

A method for treating Parkinson's disease in a patient in need thereof comprising administering to the patient a composition comprising effective amounts of a Longan arillus extract, a Polygalae radix extract and an Angelicae tenuissumae radix extract,
wherein the extracts are obtained using at least one solvent selected from the group consisting of water, ethanol, propanol, and butanol.

### Claim 2 (depends on 1)

The method according to claim 1, wherein the extract combination further comprises at least one extract selected from the group consisting of Puerariae radix extract, Scutellaria radix extract, Platycodi radix extract, Angelicae Dahuricae radix extract, Cimicifugae Rhizoma extract, Raphani Semen extract, and Acorus Gramineri Rhizoma extract.

### Claim 3 (depends on 2)

The method according to claim 2, wherein the composition comprises the extracts in the following amounts: 15-20 parts by weight of Longan arillus, 10 to 15 parts by weight of Angelicae tenuissimae radix, 10 to 15 parts by weight of Polygalae radix, 15 to 20 parts by weight of Puerariae radix, 5 to 10 parts by weight of Scutellaria radix, 1 to 5 parts by weight of Platycodi radix, 5 to 10 parts by weight of Angelicae Dahuricae radix, 5 to 10 parts by weight of Cimicifugae Rhizoma, 5 to 10parts by weight of Raphani Semen and 15 to 20 parts by weight of Acorus Gramineri Rhizoma.

### Claim 4 (depends on 2)

The method according to claim 2, wherein each of the at least one extract is obtained using at least one extraction solvent selected from the group consisting of water, at least one organic solvent selected from C1-4 lower alcohol, hexane, methylene chloride, acetonitrile and acetone, and a mixed solvent thereof.