# US 9,040,100 B2 · Methods for inhibiting prostate cancer by kinases and angiogenesis inhibitory mechanisms of ball moss extract

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- Number: US 9,040,100 B2
- Document ID: US9040100B2
- Status: Granted
- Kind: B2
- Application number: 14/270,414
- Filed: 2014-05-06
- Published: 2015-01-01
- Granted: 2015-05-26
- Earliest claimed: 2012-06-05
- Applicants: Henry Lowe; Joseph L. Bryant
- Inventors: Henry Lowe; Joseph L. Bryant
- Web page: https://patentgrep.com/patent/US9040100B2

## CPC

- A61K 31/575: substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
- A61K 36/88: Liliopsida (monocotyledons)
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)

## Abstract

A method of treating prostate cancer by administering a pharmaceutically-acceptable amount of a crude extract of the indigenous Jamaican plant Ball Moss (Tillandsia Recurvata) comprising one or more cycloartane isolates, and the isolates used in the method for eliciting thereby a kinase inhibitory response of prostate cancer cells by selectively inhibiting MRCKα kinase and angiogenesis of (growth of new blood vessels) to reduce the viability of prostate cancer cells. The method and compounds holds promise as a chemopreventive agent, without causing excessive damage to normal cells.

## Claims

### Claim 1

An ethanol and dichloromethane extract of Jamaican ball moss.