# US 9,040,097 B2 · Compositions for improving skin appearance

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- Number: US 9,040,097 B2
- Document ID: US9040097B2
- Status: Granted
- Kind: B2
- Application number: 13/841,352
- Filed: 2013-03-15
- Published: 2014-09-18
- Granted: 2015-05-26
- Earliest claimed: 2013-03-15
- Assignees: Indermica, Inc.
- Applicants: Inderma, Inc.
- Inventors: Eva Claiborne; Jennifer Clara Ellis
- Web page: https://patentgrep.com/patent/US9040097B2

## CPC

- A61K 8/345: {containing more than one hydroxy group}
- A61K 8/64: Proteins; Peptides; Derivatives or degradation products thereof
- A61K 8/645: {Proteins of vegetable origin; Derivatives or degradation products thereof}
- A61K 8/66: Enzymes
- A61K 8/70: containing perfluoro groups, e.g. perfluoroethers
- A61K 8/8152: {Homopolymers or copolymers of esters, e.g. (meth)acrylic acid esters; Compositions of derivatives of such polymers}
- A61K 8/8182: {Copolymers of vinyl-pyrrolidones. Compositions of derivatives of such polymers}
- A61K 8/9706: Algae
- A61K 8/9789: Magnoliopsida [dicotyledons]
- A61K 8/9794: Liliopsida [monocotyledons]
- A61Q 19/08: Anti-ageing preparations
- A61K 2800/782: Enzyme inhibitors; Enzyme antagonists
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS

## Abstract

Compositions for reducing the appearance of wrinkles, reducing the effects of aging and/or improving the appearance of skin. The composition may include at least one fluorinated perfluorocarbon; stem cells from at least one plant species; and at least one peptide complex that reduces release of acetylcholine. Other embodied compositions include at least one collagen stimulating peptide; at least one anti-inflammatory compound; and at least one skin tightening agent.

## Claims

### Claim 1

A composition comprising:
a. at least one fluorinated perfluorocarbon;
b. stem cells from at least one plant species;
c. at least one peptide complex that reduces release of acetylcholine; and
d. a cosmetically acceptable carrier.

### Claim 2 (depends on 1)

The composition according to claim 1, wherein said fluorinated perfluorocarbon is perfluorohexane, perfluoroperhydrophenanthrene, perfluorodecalin, perfluorodimethylcyclohexane, pentafluoropropane or a combination thereof.

### Claim 3 (depends on 1)

The composition according to claim 1, wherein said stem cells are from a grape vine, a rose plant, an apple tree, an argan tree or a combination thereof.

### Claim 4 (depends on 1)

The composition according to claim 1, wherein said peptide complex is hexapeptide-3, acetyl-hexapeptide-8, pentapeptide-3, acetyl glutamyl heptapeptide-1, heptapeptide.

### Claim 5 (depends on 1)

The composition according to claim 1, comprising stem cells from at least two plant species, at least two peptide complexes that reduce release of acetylcholine or both.

### Claim 6 (depends on 1)

A composition according to claim 1, wherein the cosmetically acceptable carrier includes one more of a surfactant, an emulsifier, a foam modulator, a viscosity modifier, a humectant, a diluent, a filler, a pH modifying agent, a colorant, a solvent, a preservative, a thickener, a perfume, an emollients, a vitamin, a mineral, a moisturizer, or a combination thereof.

### Claim 7 (depends on 1)

The composition of claim 1, wherein said composition is provided in a serum, cream, gel, emulsion, spray, powder, lotion, ointment, soap, or stick.

### Claim 8 (depends on 1)

A method for reducing the appearance of wrinkles on skin comprising applying the composition according to claim 1 to a portion of skin.