# US 9,040,095 B2 · Colon cleansing of residual stool and secretions during colonoscopy > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 9,040,095 B2 - Document ID: US9040095B2 - Status: Granted - Kind: B2 - Application number: 13/502,344 - Filed: 2010-10-14 - Published: 2012-08-30 - Granted: 2015-05-26 - Earliest claimed: 2009-10-14 - Assignees: Gi Innovations, Pllc - Applicants: Rayees Nizam - Inventors: Rayees Nizam - Web page: https://patentgrep.com/patent/US9040095B2 ## CPC - A61K 31/80: Polymers containing hetero atoms not provided for in groups A61K31/755 - A61K31/795 - A61B 1/015: Control of fluid supply or evacuation - A61B 1/31: for the rectum, e.g. proctoscopes or sigmoidoscopes - A61K 9/0053: {Mouth and digestive tract, i.e. intraoral and peroral administration} - A61K 9/08: Solutions {(composition of solutions A61K47/00)} - A61K 31/195: having an amino group - A61K 31/198: Alpha-amino acids, e.g. alanine or edetic acid [EDTA] (betaine A61K31/205; proline A61K31/401; tryptophan A61K31/405; histidine A61K31/4172; peptides not degraded to individual amino acids A61K38/00) - A61K 31/22: of acyclic acids, e.g. pravastatin - A61K 31/225: Polycarboxylic acids - A61K 31/695: Silicon compounds - A61M 31/00: Devices for introducing or retaining media, e.g. remedies, in cavities of the body (A61M25/00 takes precedence {; introducing or retaining ophthalmic products into the ocular cavities A61F9/0008}) - A61P 1/00: Drugs for disorders of the alimentary tract or the digestive system - A61P 1/10: Laxatives - G06Q 30/0239: {Online discounts or incentives} - G06Q 30/0241: Advertisements - H04L 51/04: Real-time or near real-time messaging, e.g. instant messaging [IM] - H04L 51/216: Handling conversation history, e.g. grouping of messages in sessions or threads - H04W 4/025: {using location based information parameters} - A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D) - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) - A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)} - A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS - G06Q: INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR ADMINISTRATIVE, COMMERCIAL, FINANCIAL, MANAGERIAL OR SUPERVISORY PURPOSES; SYSTEMS OR METHODS SPECIALLY ADAPTED FOR ADMINISTRATIVE, COMMERCIAL, FINANCIAL, MANAGERIAL OR SUPERVISORY PURPOSES, NOT OTHERWISE PROVIDED FOR - H04L: TRANSMISSION OF DIGITAL INFORMATION, e.g. TELEGRAPHIC COMMUNICATION (arrangements common to telegraphic and telephonic communication H04M) - H04W: WIRELESS COMMUNICATION NETWORKS (broadcast communication H04H; communication systems using wireless links for non-selective communication, e.g. wireless extensions H04M1/72) ## Abstract This invention relates, e.g., to a composition comprising two or more of: (a) N-acetylcysteine and/or (b) simethicone and/or (c) a docusate salt. In one embodiment of the invention, the amounts of (a) and/or (b) and/or (c) are effective, when the composition is administered into a colon of a subject undergoing colonoscopy, to cleanse a region of the colon in the visual field of the colonoscope so that the region contains no adherent stool or intestinal secretions obscuring the visual field. Methods for using this or other compositions of the invention, e.g. to cleanse the colon of a subject in order to enhance visualization of the colon during a colonoscopy, are also described, as are kits for carrying out methods of the invention. ## Claims ### Claim 1 A method for cleansing the colon of a subject during a colonoscopy screening procedure, comprising during the colonoscopy introducing into the lumen of the colon of the subject, through a channel in a colonoscope, a liquid form of a composition comprising: a) N-acetylcysteine and one or both of b) simethicone or c) a docusate salt, wherein the amounts of a), b) and c), are effective, when administered through a colonoscope, in two or fewer flushes, to cleanse stool from the colon of the subject such that a region of the colon in the visual field of the colonoscope contains substantially no adherent stool or intestinal secretions, and wherein the concentrations of a), b) and c) are a) N-acetylcysteine: from about 20 mg to 20 g/L, b) simethicone: from about 3 mg to 3 g/L, c) a docusate salt: from about 2 mg to 2 g/L. ### Claim 2 (depends on 1) The method of claim 1, wherein the composition comprises N-acetylcysteine and simethicone and a docusate salt. ### Claim 3 (depends on 1) The method of claim 1, wherein introduction into the lumen of the colon through the colonoscope comprises operating a pump which is operably linked via a conduit to a container that comprises the composition comprising a) N-acetylcysteine and one or both of b) simethicone, or c) a docusate salt, wherein the amounts of a), b) and c), are effective, when administered through a colonoscope, in two or fewer flushes, to cleanse stool from the colon of the subject such that a region of the colon in the visual field of the colonoscope contains substantially no adherent stool or intestinal secretions, allowing inflow of the composition from the container to the pump, and is also operably linked via a channel to a colonoscope, allowing outflow of the composition from the pump to the channel in the colonoscope, thereby administering the composition to the lumen of the colon. ### Claim 4 (depends on 1) The method of claim 1, wherein introduction into the lumen of the colon through the colonoscope comprises introducing, with a syringe, the composition comprising a) N-acetylcysteine and one or both of b) simethicone, or c) a docusate salt, wherein the amounts of a), b) and c), are effective, when administered through a colonoscope, in two or fewer flushes, to cleanse stool from the colon of the subject such that a region of the colon in the visual field of the colonoscope contains substantially no adherent stool or intestinal secretions into a channel in the colonoscope, thereby administering the composition to the subject. ### Claim 5 (depends on 1) The method of claim 1, wherein the N-acetylcysteine is in an amount of about 2 g/L.