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US 9,040,090 B2Granted
Isolated and fixed micro and nano structures and methods thereof
AssigneeThe University of North Carolina at Chapel Hill
InventorsJoseph M. DeSimone, Ginger Denison Rothrock, Benjamin W. Maynor, Jason P. Rolland
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Abstract
Discrete micro and nanoscale particles are formed in predetermined shapes and sizes and predetermined size dispersions. The particles can also be attached to a film to form arrays of particles on a film. The particles are formed from molding techniques that can include high throughput and continuous particle molding.
Claims51
A delivery device, comprising:
- a dissolvable substrate of a first material, wherein the dissolvable substrate is dissolvable in biological tissues;
- and
- a plurality of substantially monodisperse particles configured from a second material;
- each particle of the plurality comprising:
- a predetermined, non-spherical three-dimensional geometric solid shape;
- parallel lateral surfaces and parallel top and bottom surfaces in cross-section;
- and
- a maximum cross-sectional dimension of less than about 10 micrometers;
- wherein
- the plurality of substantially monodisperse particles are coupled with the dissolvable substrate in a substantially predetermined orientation.
7 more elements
Dependencies are inferred from the claim text.