# US 9,040,075 B2 · Method of increasing lean body mass and reducing body fat mass in infants > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 9,040,075 B2 - Document ID: US9040075B2 - Status: Granted - Kind: B2 - Application number: 10/576,522 - Filed: 2004-12-17 - Published: 2007-02-01 - Granted: 2015-05-26 - Earliest claimed: 2003-12-19 - Assignees: Abbott Laboratories - Applicants: Nancy Auestad; Joan R. Jacobs - Inventors: Nancy Auestad; Joan R. Jacobs - Web page: https://patentgrep.com/patent/US9040075B2 ## CPC - A23L 33/30: {Dietetic or nutritional methods, e.g. for losing weight (A23L33/10 takes precedence)} - A23L 33/12: Fatty acids or derivatives thereof - A23L 33/40: {Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula} - A61K 31/202: having three or more double bonds, e.g. linolenic (eicosanoids, e.g. leukotrienes A61K31/557) - A23V 2002/00: Food compositions, function of food ingredients or processes for food or foodstuffs - A23L: FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF (preservation thereof A23B) - A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D) - A23V: INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION ## Abstract Disclosed is a method of increasing lean body mass and reducing fat body mass in infants, said method comprising administration to an infant, term or preterm, a nutritional formula comprising a source of DHA and ARA. It has been found that the administration of DHA and ARA, or a source thereof, in infants can increase lean body mass and reduce fat body mass, when compared to an unsupplemented control formula, without impacting the total overall growth of the infant. This method is especially useful in preterm infants. ## Claims ### Claim 1 A method of increasing lean body mass and reducing fat body mass in preterm infants, said method comprising: feeding the preterm infant in need of such treatment a nutritional formula comprising DHA and ARA from fish and fungal oil, wherein the DHA is present in an amount from 0.1 to 0.3% by weight of fat, and the ARA is present in an amount from 0.4 to 0.5% by weight of fat; and evaluating the lean body mass and fat body mass of the preterm infant after feeding the preterm infant the nutritional formula. ### Claim 2 (depends on 1) The method of claim 1 wherein the fat body mass of the preterm infant is reduced by at least about 15% at 12 months corrected age as compared to preterm infants fed the control nutritional formula. ### Claim 3 A method of increasing lean body mass and reducing fat body mass in preterm infants, said method comprising feeding the preterm infant in need of such treatment a nutritional formula comprising DHA and ARA from egg-derived triglyceride and fish oil, wherein the DHA is present in an amount from 0.1 to 0.3% by weight of fat, and the ARA is present in an amount from 0.4 to 0.5% by weight of fat; and evaluating the lean body mass and fat body mass of the preterm infant after feeding the preterm infant the nutritional formula. ### Claim 4 (depends on 3) The method of claim 3 wherein the fat body mass of the preterm infant is reduced by at least about 15% at 12 months corrected age as compared to preterm infants fed the control nutritional formula. ### Claim 5 A method of increasing lean body mass and reducing fat body mass in preterm infants, said method comprising feeding the preterm infant in need of such treatment a nutritional formula comprising a source of DHA and ARA selected from the group consisting of fungal oil, egg-derived triglyceride, fish oil, and combinations thereof, wherein the DHA is present in an amount from 0.1 to 0.3% by weight of fat, and the ARA is present in an amount from 0.4 to 0.5% by weight of fat; and evaluating the lean body mass and fat body mass of the preterm infant after feeding the preterm infant the nutritional formula. ### Claim 6 A method of increasing lean body mass and reducing fat body mass in infants, said method comprising: feeding the infant in need of such treatment a nutritional formula comprising a source of DHA and ARA, wherein the DHA is present in an amount from 0.1 to 0.3% by weight of fat, and the ARA is present in an amount from 0.4 to 0.5% by weight of fat; and evaluating the lean body mass and fat body mass of the infant after feeding the infant the nutritional formula. ### Claim 7 (depends on 6) The method of claim 6, wherein the feeding provides the infant with an average daily intake per kg body weight of from about 2 to about 65 mg DHA and from about 2 to about 65 mg ARA. ### Claim 8 (depends on 6) The method of claim 6, wherein the feeding provides the infant with an average daily intake per kg body weight of from about 3 to about 35 mg DHA and from about 5 to about 50 mg ARA. ### Claim 9 (depends on 6) The method of claim 6, wherein the feeding provides the infant with an average daily intake per kg body weight of from about 7 to about 26 mg DHA and from about 20 to about 40 mg ARA. ### Claim 10 (depends on 6) The method of claim 6, wherein the daily feeding is applied to infants that are less than about 1 year corrected age. ### Claim 11 (depends on 6) The method of claim 6, wherein the nutritional formula further comprises protein, lipid and carbohydrate. ### Claim 12 (depends on 6) The method of claim 6, wherein the nutritional formula provides a caloric density of from about 19 kcal/fl oz to about 24 kcal/fl oz. ### Claim 13 (depends on 6) The method of claim 6, wherein the nutritional formula comprises per each 100 kcal of said formula: (A) from about 3 grams to about 8 grams of lipid; (B) from about 1 gram to about 3.5 grams of protein; and (C) from about 8 grams to about 16 grams of carbohydrate. ### Claim 14 (depends on 6) The method of claim 6, wherein the nutritional formula comprises per each 100 kcal of said formula: (A) from about 4 grams to about 6.6 grams of lipid; (B) from about 1.5 gram to about 3.4 grams of protein; and (C) from about 9 grams to about 13 grams of carbohydrate.