# US 9,040,066 B2 · Skin rejuvenation cream > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 9,040,066 B2 - Document ID: US9040066B2 - Status: Granted - Kind: B2 - Application number: 14/246,242 - Filed: 2014-04-07 - Published: 2014-08-07 - Granted: 2015-05-26 - Earliest claimed: 2006-12-26 - Assignees: Ad Lunam Labs, Inc. - Applicants: William H. Beeson; Alvin T. Rockhill - Inventors: William H. Beeson; Alvin T. Rockhill - Web page: https://patentgrep.com/patent/US9040066B2 ## CPC - A61K 8/368: with carboxyl groups directly bound to carbon atoms of aromatic rings - A61K 8/27: Zinc; Compounds thereof - A61K 8/37: Esters of carboxylic acids - A61K 8/44: Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof - A61K 8/498: {having 6-membered rings or their condensed derivatives, e.g. coumarin} - A61K 8/64: Proteins; Peptides; Derivatives or degradation products thereof - A61K 8/676: {Ascorbic acid, i.e. vitamin C} - A61K 8/678: {Tocopherol, i.e. vitamin E} - A61K 31/355: Tocopherols, e.g. vitamin E - A61K 31/375: Ascorbic acid, i.e. vitamin C; Salts thereof - A61P 17/00: Drugs for dermatological disorders - A61Q 19/00: Preparations for care of the skin - A61Q 19/08: Anti-ageing preparations - A61K 31/19: Carboxylic acids, e.g. valproic acid (salicylic acid A61K31/60) - A61K 36/55: Linaceae (Flax family), e.g. Linum - A61K 38/095: Oxytocins; Vasopressins; Related peptides - A61K 47/12: Carboxylic acids; Salts or anhydrides thereof - A61K 47/46: Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts - A61K 2300/00: Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00 - A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D) - A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS - A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS ## Abstract This invention is based upon the discovery that a mixture of ethyl lactate and isoamyl lactate can be used to improve the penetration of active ingredients in skin care formulations through the outer layers of the stratum corneum and viable epidermis and into the dermis layer of the skin structure. The present invention more specifically discloses a method of rejuvenating skin comprising topically applying a topical formulation to the skin, wherein the topical formulation is comprised of ascorbic acid, an amino acid selected from the group consisting of phenylalanine and tyrosine, a non-toxic zinc salt, carnosic acid, α-tocopherol, 0.01 weight percent to 20 weight percent of a mixture of ethyl lactate and isoamyl lactate, wherein the weight ratio of the ethyl lactate to the isoamyl lactate is within the range of 1:10 to 20:1, and a pharmaceutically acceptable carrier. ## Claims ### Claim 1 A method of rejuvenating skin affected by intrinsic aging and/or photo-induced aging, said method comprising topically applying a topical formulation to the skin, wherein said topical formulation is comprised of about 1 weight percent to about 20 weight percent ascorbic acid, about 1 weight percent to about 10 weight percent of phenylalanine, about 0.5 weight percent to about 5 weight percent of a non-toxic zinc salt, a marjoram extract containing carnosic acid, about 1 weight percent to about 30 weight percent α-tocopherol, and about 0.01 weight percent to about 20 weight percent of a mixture of ethyl lactate and isoamyl lactate, wherein the weight ratio of ethyl lactate to isoamyl lactate is within the range of about 1:10 to about 20:1, and a pharmaceutically acceptable carrier. ### Claim 2 (depends on 1) The method as specified in claim 1 wherein the ethyl lactate and the isoamyl lactate are provided to the topical formulation by the marjoram extract which is a liquid system that includes water, the ethyl lactate, and the isoamyl lactate. ### Claim 3 (depends on 1) The method as specified in claim 1 wherein the marjoram extract is made by (1) heating a mixture of marjoram leaves in a mixture of water, ethyl lactate, and isoamyl lactate at an elevated temperature which is within the range of about 70° C. to about 100° C. to produce a mixture of the marjoram extract and solid matter, and (2) recovering the marjoram extract from the mixture by filtering out the solid matter. ### Claim 4 (depends on 1) The method as specified in claim 1 wherein the mixture of ethyl lactate and isoamyl lactate is present at a level which is within the range of about 0.01 weight percent to about 1 weight percent. ### Claim 5 (depends on 1) The method as specified in claim 1 wherein the mixture of ethyl lactate and isoamyl lactate is present at a level which is within the range of about 0.01 weight percent to about 0.5 weight percent. ### Claim 6 (depends on 1) The method as specified in claim 1 wherein the pharmaceutically acceptable carrier is an oil-in-water emulsion. ### Claim 7 (depends on 6) The method as specified in claim 6 wherein the oil-in-water emulsion includes white petrolatum. ### Claim 8 (depends on 7) The method as specified in claim 7 wherein the oil-in-water emulsion is further comprised of cetearyl alcohol, sorbitol, propylene glycol, simethicone, glyceryl monostearate, polyethylene glycol monostearate, and sorbic acid.