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US 9,040,062 B2Granted
Preparation for treatment of spinal cord injury
AssigneesSumitomo Dainippon Pharma Co., Ltd., Keio University
InventorsMiho Maeda, Akiyoshi Kishino, Akihiko Sano, Hideyuki Okano, Masaya Nakamura, Liang Zhang
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Abstract
The present invention is a solid sustained-release formulation comprising an agent for inhibiting semaphorin 3A as an active ingredient, which comprises an agent for inhibiting semaphorin 3A and pharmaceutically acceptable hardly water-soluble solid substance, in which the carrier is silicone.
Claims17
A sustained-release formulation having a solid sheet or rod shape comprising:
- a compound of Formula (1):
- wherein R1 is a hydrogen atom or a carboxyl group, R2 is a hydrogen atom or a hydroxyl group, R3 is a hydrogen atom or a carboxyl group, and R4 is a hydrogen atom or a hydroxyl group, or
- a pharmaceutically acceptable salt thereof;
- at least one water-insoluble or hardly water-soluble substance selected from the group consisting of a low substituted hydroxypropylcellulose, a partly pregelatinized starch, crospovidone, croscarmellose sodium, carmellose calcium, hydroxypropyl starch, myristic acid, lauric acid, palmitic acid, saccharin and cholesterol;
- and
- a silicone biocompatible hydrophobic polymer.
3 more elements
A sustained-release formulation having a solid sheet or rod shape consisting essentially of:
- a compound of Formula (1):
- wherein R1 is a hydrogen atom or a carboxyl group, R2 is a hydrogen atom or a hydroxyl group, R3 is a hydrogen atom or a carboxyl group, and R4 is a hydrogen atom or a hydroxyl group, or
- a pharmaceutically acceptable salt thereof;
- at least one water-insoluble or hardly water-soluble substance selected from the group consisting of a low substituted hydroxypropylcellulose, a partly pregelatinized starch, crospovidone, croscarmellose sodium, carmellose calcium, hydroxypropyl starch, myristic acid, lauric acid, palmitic acid, saccharin and cholesterol;
- a silicone biocompatible hydrophobic polymer;
- and
- optionally a water-soluble additive agent.
4 more elements
Dependencies are inferred from the claim text.