# US 9,040,054 B2 · Hypoallergenic molecules

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- Number: US 9,040,054 B2
- Document ID: US9040054B2
- Status: Granted
- Kind: B2
- Application number: 12/674,195
- Filed: 2008-06-30
- Published: 2011-09-08
- Granted: 2015-05-26
- Earliest claimed: 2007-08-21
- Assignees: Biomay AG
- Applicants: Michael Wallner; Barbara Bohle; Martin Himly; Nicole Wopfner; Gabriele Gadermaier; Matthias Egger; Peter Lackner; Fatima Ferreira; Michael Hauser
- Inventors: Michael Wallner; Barbara Bohle; Martin Himly; Nicole Wopfner; Gabriele Gadermaier; Matthias Egger; Peter Lackner; Fatima Ferreira; Michael Hauser
- Web page: https://patentgrep.com/patent/US9040054B2

## CPC

- C07K 14/415: from plants
- A61P 37/08: Antiallergic agents (antiasthmatic agents A61P11/06; ophthalmic antiallergics A61P27/14)
- C07K: PEPTIDES (peptides in foodstuffs A23; obtaining protein compositions for foodstuffs, working-up proteins for foodstuffs A23J; preparations for medicinal purposes A61K; peptides containing beta-lactam rings C07D; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, C07D; ergot alkaloids of the cyclic peptide type C07D519/02; macromolecular compounds having statistically distributed amino acid units in their molecules, i.e. when the preparation does not provide for a specific; but for a random sequence of the amino acid units, homopolyamides and block copolyamides derived from amino acids C08G69/00; macromolecular products derived from proteins C08H1/00; preparation of glue or gelatine C09H; single cell proteins, enzymes C12N; genetic engineering processes for obtaining peptides C12N15/00; compositions for measuring or testing processes involving enzymes C12Q; investigation or analysis of biological material G01N33/00)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

The present invention relates to a hypoallergenic molecule consisting of Bet v Ia or an allergen having at least 40% identity to Bet v Ia comprising mutations of at least four amino acid residues in the region of amino acids 100 to 125 of Bet v Ia or its corresponding region of the allergen having at least 40% identity to Bet v 1a.

## Claims

### Claim 1

A mutant polypeptide, comprising SEQ ID NO:3.

### Claim 2 (depends on 1)

A composition, comprising the mutant polypeptide of claim 1 and at least one pharmaceutically acceptable excipient, diluent, adjuvant and/or carrier.