# US 9,040,016 B2 · Diagnostic kit and methods for radioimaging myocardial perfusion

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- Number: US 9,040,016 B2
- Document ID: US9040016B2
- Status: Granted
- Kind: B2
- Application number: 12/309,479
- Filed: 2007-07-19
- Published: 2010-01-28
- Granted: 2015-05-26
- Earliest claimed: 2004-01-13
- Assignees: Biosensors International Group, Ltd.
- Applicants: Benny Rousso; Dalia Dickman; Shlomo Ben-Haim; Simona Ben Haim
- Inventors: Benny Rousso; Dalia Dickman; Shlomo Ben-Haim; Simona Ben Haim
- Web page: https://patentgrep.com/patent/US9040016B2

## CPC

- A61B 6/4057: {by using radiation sources located in the interior of the body (A61B6/037 takes precedence)}
- A61B 5/4076: {Diagnosing or monitoring particular conditions of the nervous system}
- A61B 5/411: {Detecting or monitoring allergy or intolerance reactions to an allergenic agent or substance}
- A61B 5/415: {the glands, e.g. tonsils, adenoids or thymus}
- A61B 5/417: {the bone marrow}
- A61B 5/418: {lymph vessels, ducts or nodes}
- A61B 6/037: {Emission tomography}
- A61B 6/4258: {for detecting non x-ray radiation, e.g. gamma radiation (A61B6/037 takes precedence)}
- A61B 5/4064: {Evaluating the brain (for intracranial pressure A61B5/031; for cerebral blood gases A61B5/14553; using EEG A61B5/369)}
- A61B 6/4488: {Means for cooling (A61B6/045 takes precedence)}
- A61B 6/501: {for diagnosis of the head, e.g. neuroimaging or craniography}
- A61B 6/502: {for diagnosis of breast, i.e. mammography}
- A61B 6/503: {for diagnosis of the heart}
- A61B 6/504: {for diagnosis of blood vessels, e.g. by angiography}
- A61B 6/583: {using calibration phantoms}
- A61B 8/0891: {for diagnosis of blood vessels}
- A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D)

## Abstract

A method of radioimaging a myocardial perfusion, the method including in sequence: administering to a subject a low dose of a first radiopharmaceutical; subjecting the subject to a physical stress; administering to the subject at a peak of said physical stress a medium or high dose of a second radiopharmaceutical; and immediately radioimaging using a 3D non-coincidence imaging method a heart of the subject, thereby radioimaging a myocardial perfusion.

## Claims

### Claim 1

A method of radioimaging a myocardial perfusion while avoiding at least some liver radioactivity, the method comprising in sequence the steps of:
(a) administering to a subject a first dose of a first radiopharmaceutical;
(b) subjecting said subject to a physical stress;
(c) administering to said subject at a peak of said physical stress a second dose of a second radiopharmaceutical, said second dose being higher than said first dose; and
(d) immediately, within a time interval of less than 3 minutes from said administering in step (c), radioimaging a heart of said subject with a radioimaging camera using a 3D non-coincidence imaging method, wherein said first radiopharmaceutical comprises an isotope including Tl-201 or Tc-99m and said second radiopharmaceutical comprises an isotope including Tc-99m or Iodine-123, thereby radioimaging a myocardial perfusion.

### Claim 2 (depends on 1)

The method of claim 1, wherein said first radiopharmaceutical and said second radiopharmaceutical are identical.

### Claim 3 (depends on 1)

The method of claim 1, wherein said first radiopharmaceutical and said second radiopharmaceutical are not identical.

### Claim 4 (depends on 1)

The method of claim 1, wherein a length of time of said Steps (a)-(d) is no more than 30 minutes.

### Claim 5 (depends on 1)

The method of claim 1, further comprising radioimaging said heart of said subject following said step (a).

### Claim 6 (depends on 1)

The method of claim 1, wherein:
said step (a) comprises injection of a first dose of Tc-99m Sestamibi of between 8 and 12 mCi using an IV bolus, said step (a) further comprises up to 5 minutes of radioimaging, said step (b) comprises a physical stressing, said step (c) comprises injection of a second dose of Tc-99m Sestamibi of about 24 to about 36 mCi, at peak stress, using an IV bolus, and said step (d) further comprises 2 minutes of radioimaging to obtain heart perfusion imaging data; or
said step (a) comprises injecting a first dose of Tc-99m Sestamibi of up to about 10 mCi by IV bolus, said step (b) comprises a physical stressing; said step (c) comprises an injection of a second dose of Thallium-201 of about 3 mCi at peak stress using IV bolus, and said Step (d) further comprises up to 10 minutes of imaging using an energy window of 3-15% to obtain heart perfusion imaging data.

### Claim 7 (depends on 1)

The method of claim 1, wherein said step (a) comprises administering from a packaged dose unit of about 2.5 mrem or less per kg body weight.

### Claim 8 (depends on 7)

The method of claim 7, wherein said step (c) comprises administering from a packaged dose unit of about 30 mrem or more per kg body weight.

### Claim 9 (depends on 1)

The method of claim 1, wherein a time interval of less than 2 minutes passes between step (c) and step (d).

### Claim 10 (depends on 1)

The method of claim 1, wherein a time interval of less than 1 minute passes between step (c) and step (d).