Bioprinting station, assembly comprising such bioprinting station and bioprinting method

Bioprinting station comprising:

• i) a Bioprinting device adapted to deposit a pattern of biological material onto an area of interest of a substrate, said area of interest having a feature that distinguishes said area of interest from a remaining part of the substrate, said Bioprinting device comprising:
• at least one biological material dispenser adapted to dispense the biological material to be deposited, and
• a positioning system adapted to receive the substrate and to position the area of interest with respect to the dispenser, wherein the dispenser comprises:
• a) a holding device for holding at least one ribbon containing the biological material, the holding device being provided with at least one opened working space adapted to receive at least a part of the ribbon, and
• b) a laser system arranged for emitting a laser beam adapted to transfer the biological material from the ribbon to the substrate,
• wherein the laser system comprises a laser device for emitting the laser beam and an optical scanning device adapted to orient the laser beam within the opened working space,
• ii) an imaging system configured to acquire an image of the substrate and to reveal on the acquired image the feature of the area of interest with respect to the remaining part;
• and
• iii) an electronic control unit configured to:
• first, drive the imaging system according to an optical pathway to acquire an image of the substrate, the substrate being scanned by moving the optical pathway along the substrate through the optical scanning device of the laser device,
• second, process the acquired image of the substrate so as to detect the revealed area of interest on the acquired image,
• third, determine the pattern corresponding to the area of interest detected on the acquired image,
• fourth, drive the holding device and the positioning system relative to one another so that the opened working space faces the area of interest,
• fifth, deposit the biological material according to the pattern within the opened working space by driving the laser system and the positioning system relative to one another.