# US 9,039,877 B2 · Electrode strip and sensor strip and manufacture method thereof and system thereof

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- Number: US 9,039,877 B2
- Document ID: US9039877B2
- Status: Granted
- Kind: B2
- Application number: 13/725,244
- Filed: 2012-12-21
- Published: 2014-01-23
- Granted: 2015-05-26
- Earliest claimed: 2012-07-20
- Assignees: Apex Biotechnology Corp.
- Applicants: Apex Biotechnology Corp.
- Inventors: Ying-Che Huang; Lan-Hsiang Huang; Ching-Yuan Chu
- Web page: https://patentgrep.com/patent/US9039877B2

## CPC

- G01N 27/4166: {measuring a particular property of an electrolyte}
- C12Q 1/001: {Enzyme electrodes}
- C12Q 1/005: {involving specific analytes or enzymes (including groups of enzymes, e.g. oxydases; C12Q1/004 takes precedence)}
- G01N 27/3271: {Amperometric enzyme electrodes for analytes in body fluids, e.g. glucose in blood (amperometry per se G01N27/49; aspects concerning the enzyme reagent C12Q1/001)}
- G01N 27/3273: {Devices therefor, e.g. test element readers, circuitry (details not specific to biochemical electrodes G01N33/4875)}
- G01N 27/3274: {Corrective measures, e.g. error detection, compensation for temperature or hematocrit, calibration (coding of calibration information G01N33/48771)}
- G01N 33/80: involving blood groups or blood types {or red blood cells (white blood cells G01N33/56972)}
- Y10T 156/10: Methods of surface bonding and/or assembly therefor
- Y10T 156/1052: with cutting, punching, tearing or severing
- Y10T 156/1057: Subsequent to assembly of laminae
- G01N: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES (measuring or testing apparatus or processes other than immunoassay, involving enzymes or microorganisms C12M, C12Q)
- C12Q: MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS (immunoassay G01N33/53); COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- Y10T: TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION

## Abstract

The present disclosure relates to an electrode strip, a sensor strip, a system thereof and a manufacturing method thereof. The sensor strip includes a first reactive film, a second reactive film and a vent hole. The first reactive film includes a substrate, a first electrode layer and a first insulation layer. The first end of the first insulation layer is concaved to a first depth to form a first reactive area. The second reactive film includes a second electrode layer and a second insulation layer. The first end of the second insulation layer is concaved to a second depth to form a second reactive area. The vent hole penetrates the second insulation layer, the second electrode layer and the first insulation layer so as to connect the first reactive area and the second reactive area.

## Claims

### Claim 1

A sensor strip, comprising:
a first reactive film including:
a substrate;
a first electrode layer disposed directly on the substrate; and
an first insulation layer including a first end and disposed on the first electrode layer, wherein the first end is concaved to form a first reactive area with a first depth;
a second reactive film including:
a second electrode layer disposed directly on the first insulation layer; and
a second insulation layer including a first end and disposed on the second electrode layer, wherein the first end of the second insulation layer is concaved to form a second reactive area with a second depth; and
a vent hole penetrating the second insulation layer, the second electrode layer and the first insulation layer and connecting the first reactive area and the second reactive area,
wherein the first electrode layer, the first insulation layer, the second electrode layer and the second insulation layer are disposed on one side of the substrate.

### Claim 2 (depends on 1)

The sensor strip according to claim 1, wherein the first end of the first insulation layer adjacent to the first electrode layer is concaved to form the first reactive area, and a sampling opening with a third depth is concaved and formed next to the first reactive area, and wherein either the first depth or the second depth is longer than the third depth and wherein the first reactive area and the second reactive area accommodate samples from an identical source and the first depth and the second depth are configured to separate the sample of the first reactive area from the sample of the second reactive area.

### Claim 3 (depends on 2)

The sensor strip according to claim 2, wherein an inside diameter of the first reactive area is larger or smaller than an inside diameter of the sampling opening and wherein an inside diameter of the second reactive area is larger or smaller than an insider diameter of the sampling opening and wherein the first end of the first insulation layer away from the substrate is a hydrophobic surface and wherein the first insulation layer further includes a second end, the first electrode layer includes at least one electrode, and the first insulation layer exposes the at least one electrode adjacent to the second end.

### Claim 4

An electrode strip, comprising:
a first substrate;
a first electrode set disposed directly on the first substrate;
a first insulation layer including a first opening and disposed on the first electrode set;
a second substrate disposed on the first insulation layer and including a sampling opening and a connecting hole;
a second electrode set disposed directly on the second substrate and uncovering the connecting hole; and
a second insulation layer including a second opening, wherein the connecting hole vertically connects the first opening and the second opening,
wherein the first electrode set, the first insulation layer, the second substrate, the second electrode set and the second insulation layer are disposed on one side of the first substrate.

### Claim 5 (depends on 4)

The electrode strip according to claim 4, further comprising a cover disposed on the second insulation layer, wherein the cover includes a through hole connecting with the connecting hole and wherein the second opening located between the cover and the second substrate to form a second reactive area, and the first opening is located between the first substrate and the second substrate to form a first reactive area,
wherein the cover is disposed on the same side of the first electrode set, the first insulation layer, the second substrate, the second electrode set and the second insulation layer.

### Claim 6 (depends on 5)

The electrode strip according to claim 5, wherein the first reactive area includes a first depth, the second reactive area includes a second depth, the sampling opening includes a third depth and wherein either the first depth or the second depth is longer than the third depth, the first reactive area and the second reactive area accommodate samples from the same source, the first depth and the second depth are configured to separate the sample of the first reactive area from the sample of the second reactive area.

### Claim 7 (depends on 6)

The electrode strip according to claim 6, wherein an inside diameter of the first opening where the first reactive area is located is equal to an inside diameter of the sampling opening, and an inside diameter of the second opening where the second reactive area is located is equal to an inside diameter of the sampling opening.

### Claim 8 (depends on 4)

The electrode strip according to claim 4, wherein an inside diameter of the first opening is larger or smaller than an inside diameter of the sampling opening, and an inside diameter of the second opening is larger or smaller than an inside diameter of the sampling opening.

### Claim 9 (depends on 4)

The electrode strip according to claim 4, wherein an end of the second substrate, where the sampling opening is formed, is a hydrophobic surface and wherein the first insulation layer exposes a connection of the first electrode set away from the first opening, the second insulation layer exposes a connection of the second electrode set away from the second opening, and the connection of the first electrode set does not overlap with the connection of the second electrode set.

### Claim 10 (depends on 4)

The electrode strip according to claim 4, wherein the second substrate includes an awl-shaped end where the sampling opening is located, and the sampling opening is located at a tip area of the awl-like shaped end.

### Claim 11 (depends on 4)

The electrode strip according to claim 4, wherein the sampling opening is disposed at a corner of the second substrate, a lengthwise axis of the first opening and a lengthwise axis of the first insulation layer intersect to form an included angle.