# US 9,039,687 B2 · Reactance changes to identify and evaluate cryo ablation lesions

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- Number: US 9,039,687 B2
- Document ID: US9039687B2
- Status: Granted
- Kind: B2
- Application number: 12/914,782
- Filed: 2010-10-28
- Published: 2012-05-03
- Granted: 2015-05-26
- Earliest claimed: 2010-10-28
- Assignees: Medtronic Ablation Frontiers LLC
- Applicants: Catherine R. Condie; Kathryn Elaine Kasischke; Marshall L. Sherman
- Inventors: Catherine R. Condie; Kathryn Elaine Kasischke; Marshall L. Sherman
- Web page: https://patentgrep.com/patent/US9039687B2

## CPC

- A61B 5/0538: invasively, e.g. using a catheter
- A61B 2017/00026: {Conductivity or impedance, e.g. of tissue}
- A61B 2018/00755: {Resistance or impedance}
- A61B 2018/0262: {using a circulating cryogenic fluid}
- A61B 2018/1407: {Loop}
- A61B 2018/1467: {using more than two electrodes on a single probe}
- A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D)

## Abstract

A method of assessing lesion quality of an ablated tissue region comprising ablating at least a portion of the tissue region. The reactance of the ablated tissue region is measured at a plurality of frequencies. The lesion quality of the ablated tissue region is determined based on the measured reactance. For example, an untreated tissue reactance value and a predetermined thermally treated tissue region reactance threshold may be determined. The measured reactance at each of the plurality of frequencies is compared to the threshold to determine the lesion quality of the thermally treated tissue region. The thermal treatment of the tissue may be modified based on the lesion quality determination.

## Claims

### Claim 1

A method of assessing lesion quality of a treated tissue region comprising:
positioning a medical device proximate the tissue region and circulating coolant towards a thermally conductive region of the medical device, the medical device having at least two electrodes, the electrodes being positioned proximate the thermally conductive region;
thermally treating the tissue region;
inducing a current between the at least two electrodes at a plurality of frequencies;
measuring the reactance of the thermally treated tissue region at each of the plurality of frequencies;
defining an untreated tissue reactance value;
defining a predetermined thermally treated tissue region reactance threshold, the thermally treated tissue region reactance threshold being about a 60-90% reduction in the reactance of the untreated tissue reactance value;
comparing the measured reactance at each of the plurality of frequencies to the threshold;
determining the lesion quality of the thermally treated tissue region based on the measured reactance at each of the plurality of frequencies; and
modifying the thermally treating of the tissue based at least in part on the determination.

### Claim 2 (depends on 1)

The method of claim 1, further comprising inducing the current between at least one electrode of the at least two electrodes and a ground electrode.

### Claim 3 (depends on 1)

The method of claim 1, wherein the plurality of frequencies includes frequencies selected from at least two of about 10 kHz, 400 kHz, and 1 MHz.

### Claim 4 (depends on 1)

The method of claim 1, further comprising assessing lesion continuity based the measured reactance.

### Claim 5 (depends on 1)

The method of claim 1, wherein the thermally conductive region includes a balloon, and wherein the balloon is disposed between the at least two electrodes.

### Claim 6 (depends on 1)

The method of claim 1, wherein coolant is circulated towards the thermally conductive region of the medical device for about 5 minutes.

### Claim 7 (depends on 1)

The method of claim 1, wherein determining the lesion quality of the thermally treated tissue region includes calculating a tissue transmurality based on the comparison of the measured reactance to the threshold.

### Claim 8 (depends on 1)

The method of claim 1, further comprising cooling the tissue region to a temperature of about −60° C.