# US 9,039,632 B2 · Quantitative, non-invasive, clinical diagnosis of traumatic brain injury using VOG device for neurologic optokinetic testing > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 9,039,632 B2 - Document ID: US9039632B2 - Status: Granted - Kind: B2 - Application number: 14/336,254 - Filed: 2014-07-21 - Published: 2014-11-06 - Granted: 2015-05-26 - Earliest claimed: 2008-10-09 - Assignees: Neuro Kinetics, Inc. - Applicants: Neuro Kinetics, Inc. - Inventors: Alexander D Kiderman; Howison Schroeder; Thomas Joos; Greg Frank; Daniel Sweeney; Thomas Vernon Baker - Web page: https://patentgrep.com/patent/US9039632B2 ## CPC - A61B 3/113: for determining or recording eye movement - A61B 3/0041: {characterised by display arrangements} - A61B 3/02: Subjective types, i.e. testing apparatus requiring the active assistance of the patient - A61B 5/16: Devices for psychotechnics (using teaching or educational appliances G09B1/00 - G09B7/00); Testing reaction times {; Devices for evaluating the psychological state} - A61B 5/163: {by tracking eye movement, gaze, or pupil change} - A61B 5/4064: {Evaluating the brain (for intracranial pressure A61B5/031; for cerebral blood gases A61B5/14553; using EEG A61B5/369)} - A61B 5/6803: {Head-worn items, e.g. helmets, masks, headphones or goggles} - G02B 27/017: {Head mounted} - G02C 5/001: {specially adapted for particular purposes, not otherwise provided for or not fully classifiable according to technical characteristics, e.g. therapeutic glasses} - A61B 3/032: Devices for presenting test symbols or characters, e.g. test chart projectors (A61B3/036 takes precedence) - A61B 5/4863: {Measuring or inducing nystagmus} - G02B 27/0093: {with means for monitoring data relating to the user, e.g. head-tracking, eye-tracking} - G02B 2027/0138: {comprising image capture systems, e.g. camera} - G02B 2027/014: {comprising information/image processing systems} - G02B 2027/0187: {slaved to motion of at least a part of the body of the user, e.g. head, eye} - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) - G02B: OPTICAL ELEMENTS, SYSTEMS OR APPARATUS - G02C: SPECTACLES; SUNGLASSES OR GOGGLES INSOFAR AS THEY HAVE THE SAME FEATURES AS SPECTACLES; CONTACT LENSES (trial frames for testing the eyes A61B3/04; goggles or eyeshields not having the same features as spectacles A61F9/00) ## Abstract A portable VOG device is disclosed that will facilitate the effective and efficient screening for TBI in military personnel in forward deployed military settings or remote locations using minimally trained staff. This includes the establishment of a protocol including optokinetic testing that will provide cost effective pre-screening of military personnel prior to deployment to establish a baseline of brain function prior to possible future injury. The efficiency of the device will promote subsequent follow-up screening to assess the effectiveness of prescribed TBI treatment. Further protocols for diagnosis and rehabilitation applications using the same device will allow more advanced usage for clinicians providing ongoing evaluation and treatment. ## Claims ### Claim 1 A method of diagnosis of traumatic brain injury or concussion in a subject comprising the steps of: A) providing a system including a stimulus generating portion and an eye tracking portion; B) presenting visual stimulus to the subject via the stimulus generating portion, wherein the visual stimulus presented to the subject via the stimulus generating portion forms the optical target stimulus for at least one optokinetic test; C) obtaining objective physiologic response of the subject in the form of reflexive ocular-motor responses of the subject's eyes from the eye tracking portion based upon each of the visual stimulus presented to the subject in each optokinetic test; and D) using the objective physiologic responses including the reflexive ocular-motor responses of the subject's eyes to the optical target stimulus of each optokinetic test to diagnose the presence of traumatic brain injury. ### Claim 2 (depends on 1) The method of diagnosis of traumatic brain injury according to claim 1, further including the step of obtaining pre-trauma objective physiologic responses of the subject from based upon each of the visual stimulus presented to the subject for each optokinetic test, wherein the pre-trauma objective physiologic responses for each optokinetic test form a baseline for the subject. ### Claim 3 (depends on 2) The method of diagnosis of traumatic brain injury according to claim 2, wherein the step of using the objective physiologic responses to diagnose the presence of traumatic brain injury includes a determining whether at least one post-trauma objective physiologic responses of the subject differs from the associated pre-trauma objective physiologic response by greater than a preset threshold for that response. ### Claim 4 (depends on 1) The method of diagnosis of traumatic brain injury according to claim 1, wherein the step of using the objective physiologic responses to diagnose the presence of traumatic brain injury includes a determining whether at least one post-trauma objective physiologic responses of the subject for each optokinetic test differs from an associated objective physiologic response of a normative database of similar subjects for each optokinetic test by greater than a preset threshold for that response. ### Claim 5 A method of diagnosis of traumatic brain injury in a subject comprising the steps of: A) providing a head mounted stimulus generating eye tracking goggle unit coupled to the subject and generating a plurality of visual stimulus for the subject; B) presenting the plurality of visual stimulus to the subject, wherein each visual stimulus is presented in the eye tracking unit, wherein each visual stimulus provides a target stimulus for a distinct visual based neurologic optokinetic test; C) obtaining objective physiologic response of the subject from the eye tracking unit in the form of reflexive ocular-motor responses of the subiect's eyes based upon each of neurologic optokinetic test associated with each visual stimulus presented to the subject; and D) using the objective physiologic responses to the neurologic optokinetic tests including the reflexive ocular-motor responses of the subiect's eyes to the optical target stimulus to diagnose the presence of traumatic brain injury. ### Claim 6 (depends on 5) The method of diagnosis of traumatic brain injury according to claim 5, wherein the step of using the objective physiologic responses to diagnose the presence of traumatic brain injury includes a determining whether at least one post-trauma objective physiologic responses of the subject for each optokinetic test differs from an associated objective physiologic response of a normative database of similar subjects for each optokinetic test by greater than a preset threshold for that response. ### Claim 7 (depends on 5) The method of diagnosis of traumatic brain injury according to claim 5, further including the step of obtaining pre-trauma objective physiologic responses of the subject for each optokinetic test from the head mounted goggle unit based upon each of the visual stimulus presented to the subject for each optokinetic test, wherein the pre-trauma objective physiologic responses for each optokinetic test form a baseline for the subject. ### Claim 8 (depends on 7) The method of diagnosis of traumatic brain injury according to claim 7, wherein the step of using the objective physiologic responses to diagnose the presence of traumatic brain injury includes a determining whether at least one post-trauma objective physiologic responses of the subject differs from the associated pre-trauma objective physiologic response by greater than a preset threshold for that response.