# US 9,039,176 B2 · Corneal endothelial cell photographing apparatus > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 9,039,176 B2 - Document ID: US9039176B2 - Status: Granted - Kind: B2 - Application number: 13/435,864 - Filed: 2012-03-30 - Published: 2012-10-04 - Granted: 2015-05-26 - Earliest claimed: 2011-03-31 - Assignees: Nidek Co., Ltd. - Applicants: Naoto Honda; Michihiro Takii - Inventors: Naoto Honda; Michihiro Takii - Web page: https://patentgrep.com/patent/US9039176B2 ## CPC - A61B 3/152: {for aligning} - A61B 3/0041: {characterised by display arrangements} - A61B 3/0075: {provided with adjusting devices, e.g. operated by control lever} - A61B 3/0091: {Fixation targets for viewing direction} - A61B 3/1005: {for measuring distances inside the eye, e.g. thickness of the cornea (A61B3/11 takes precedence)} - A61B 3/145: {by video means} - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) ## Abstract A corneal endothelial cell photographing apparatus comprises: a main unit including: an illumination optical system for illuminating illumination light from an illumination light source toward a cornea of an examinee's eye from an oblique direction; an imaging optical system for obtaining a corneal endothelial cell image by receiving, through an imaging element, reflection light from the cornea including corneal endothelial cells; and a fixation optical system including a plurality of fixation targets and for guiding a fixation direction of the examinee's eye; a drive unit to relatively move the main unit with respect to the examinee's eye; a serial photographing unit to obtain endothelial images in series at different photographing positions in previously set up-and-down and right-and-left directions; and a monitor to display the obtained endothelial image. ## Claims ### Claim 1 A corneal endothelial cell photographing apparatus comprising: a main unit including: an illumination optical system for illuminating illumination light from an illumination light source toward a cornea of an examinee's eye from an oblique direction; an imaging optical system for obtaining a corneal endothelial cell image by receiving, through an imaging element, reflection light from the cornea including corneal endothelial cells; and a fixation optical system including a plurality of fixation targets and for guiding a fixation direction of the examinee's eye; a drive unit operable to relatively move the main unit with respect to the examinee's eye in a three-dimensional rectangular coordinate system having a first axis in a back-and-forth direction toward and away from the examinee's eye, a second axis in an up-and-down direction relative to the examinee's eye, and a third axis in a right-and-left direction relative to the examinee's eye; a controller configured to operate the main unit in correlation with the drive unit and the fixation optical system to obtain endothelial photographic images in series at a plurality of photographing points of a preset photographing pattern on the cornea by way of relative movement between the main unit and the cornea in at least one of the up-and-down direction and the right-and-left direction, wherein the photographing points of the preset photographing pattern are different on the cornea from one another in at least one of the up-and-down direction and the right-and-left direction; and a display control unit for causing a monitor to display the obtained endothelial image. ### Claim 2 (depends on 1) The corneal endothelial cell photographing apparatus according to claim 1, wherein the controller previously sets a fixation target group to be presented to the examinee from the fixation targets and an order of the fixation of the targets in the fixation target group to be presented, the controller is configured to control the fixation optical system to present a fixation target at a first fixation position based on the order of the fixation targets to be presented previously set in the fixation target group and control the illumination optical system and an imaging optical system to obtain an endothelial image of a first point of the cornea, the controller is configured to cause the monitor to display the endothelial image obtained of the first point of the cornea; and after the endothelial image of the first point of the cornea is obtained, the controller is configured to control the fixation optical system to change a presenting position of the fixation target to a second fixation position based on the order of the fixation targets to be presented previously set in the fixation target group, thereby causing relative movement between the main unit and the cornea in at least one of the up-and-down direction and the right-and-left direction, and control the illumination optical system and the imaging optical system to obtain an endothelial image of a second point of the cornea. ### Claim 3 (depends on 2) The corneal endothelial cell photographing apparatus according to claim 2, further including an operating part to be operated by an examiner to previously set the fixation target group to be presented to the examinee from the fixation targets. ### Claim 4 (depends on 2) The corneal endothelial cell photographing apparatus according to claim 2, further including an anterior segment observation optical system having an anterior segment imaging element to image an anterior segment of the examinee's eye, wherein the controller determines whether or not a fixation state of the examinee's eye has stabilized based on an imaging signal from the anterior segment imaging element and then starts an operation to obtain the endothelial image based on a determination result. ### Claim 5 (depends on 1) The corneal endothelial cell photographing apparatus according to claim 1, wherein the controller controls driving of the drive unit to shuttle the main unit in a predetermined direction and causes the illumination light source to emit light two or more times during movement of the main unit in a forward direction to obtain a plurality of endothelial images in a first photographing point through the imaging element, while causing the illumination light source to emit light two or more times during movement of the main unit in a backward direction to obtain a plurality of endothelial images in a second photographing point through the imaging element. ### Claim 6 (depends on 5) The corneal endothelial cell photographing apparatus according to claim 5, wherein the controller detects a light reception state of corneal reflection light on the imaging element and sets a returning position based on a detection result. ### Claim 7 (depends on 1) The corneal endothelial cell photographing apparatus according to claim 1, wherein the controller previously sets a photographing range on the cornea including the pattern of the photographing points that are different from one another in at least one of the up-and-down direction and the right-and-left direction, and the controller is configured to operate the drive unit to move the main unit in the up-and-down direction and the right-and-left direction and to operate the main unit to serially obtain endothelial images at the plurality of photographing points in the previously set photographing range. ### Claim 8 (depends on 7) The corneal endothelial cell photographing apparatus according to claim 7, further including a Z alignment detection sensor for detecting an alignment state in the back-and-forth direction with respect to the cornea at each photographing point, and wherein the controller is configured to control the drive unit based on a detection result of the Z alignment detection sensor to adjust a back-and-forth position of the main unit at each photographing point. ### Claim 9 (depends on 7) The corneal endothelial cell photographing apparatus according to claim 7, further including a setting unit to be operated by an examiner to set the photographing range on a corneal image displayed on the monitor. ### Claim 10 (depends on 7) The corneal endothelial cell photographing apparatus according to claim 7, wherein the controller moves the main unit in the back-and-forth direction at each photographing point, and serially obtains endothelial images at different photographing positions in the back-and-forth direction through the imaging element. ### Claim 11 (depends on 1) The corneal endothelial cell photographing apparatus according to claim 1, further including an XY alignment detection sensor for detecting an alignment state in the up-and-down direction and the right-and-left direction with respect to a corneal center of the examinee's eye, wherein the controller controls driving of the drive unit based on a detection result of the XY alignment detection sensor to move the main unit to the photographing points while obtaining endothelial images at the photographing points. ### Claim 12 (depends on 1) The corneal endothelial cell photographing apparatus according to claim 1, wherein the controller is configured to sequentially change the photographing points clockwise or counterclockwise. ### Claim 13 (depends on 1) The corneal endothelial cell photographing apparatus according to claim 1, wherein, when serial photographing in the up-and-down direction and the right-and-left direction is to be performed, the controller is configured to detect a relative position of the main unit with respect to the eye at each of the photographing points and perform automatic alignment to each of the photographing points. ### Claim 14 (depends on 13) The corneal endothelial cell photographing apparatus according to claim 13, wherein the controller is configured to perform automatic alignment in the back-and-forth direction to each of the photographing points. ### Claim 15 (depends on 14) The corneal endothelial cell photographing apparatus according to claim 14, wherein the controller is configured to perform automatic alignment in at least one of the up-and-down direction and the right-and-left direction to each of the photographing points.