# US 9,038,488 B2 · Systems and methods for inline sampling

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- Number: US 9,038,488 B2
- Document ID: US9038488B2
- Status: Granted
- Kind: B2
- Application number: 13/776,563
- Filed: 2013-02-25
- Published: 2013-06-27
- Granted: 2015-05-26
- Earliest claimed: 2010-02-19
- Assignees: Vertex Pharmaceuticals Incorporated
- Applicants: Vertex Pharmaceuticals, Inc.
- Inventors: James E. Sinclair; B. Albert Griffin; Minh Vuong
- Web page: https://patentgrep.com/patent/US9038488B2

## CPC

- G01N 9/02: by measuring weight of a known volume
- G01N 1/20: for flowing or falling materials ({G01N1/2035} G01N1/12, G01N1/14 take precedence)
- G01N: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES (measuring or testing apparatus or processes other than immunoassay, involving enzymes or microorganisms C12M, C12Q)

## Abstract

Methods and devices for inline sampling of a bulk material, such as a powder, are provided. The material's bulk density can be determined from samples drawn using methods and devices described herein. One embodiment of a method of sampling a material allows the material to flow through a sampling compartment, closes off the flow of material below the sampling compartment, builds up a column of material through the sampling compartment, shifts the sampling compartment to remove a slice of material in the column, and places the slice of material into a sample container. A device for sampling a material is provided in another embodiment. The device includes an inlet, an outlet aligned with the inlet, and a sample collector. The sample collector can include at least one through hole and be configured to move such that the at least one through hole can be moved into and out of alignment with the inlet and the outlet.

## Claims

### Claim 1

A device for sampling a material, the device comprising:
an inlet;
a first outlet aligned with the inlet;
a flowpath between the inlet and the first outlet;
a sample collector moveably disposed in the flowpath, wherein the sample collector comprises a first through hole and a second through hole;
a valve disposed in the flowpath below the sample collector, the valve configured to inhibit flow of the material through the first outlet while allowing flow of the material through the inlet to allow a column of the material to accumulate in the first through hole when the first through hole is disposed in the flowpath;
a second outlet not aligned with the inlet; and
wherein the sample collector is configured to move such that the first through hole and second through hole can be moved into and out of the flowpath and alternately be moved into and out of alignment with the second outlet.

### Claim 2 (depends on 1)

The device of claim 1, wherein the sample collector is configured to move such that the first and second through holes are alternately aligned with the first and second outlets, and wherein the second outlet is aligned with a sample collection container.

### Claim 3 (depends on 1)

The device of claim 1, wherein the sample collector is a disc.

### Claim 4 (depends on 3)

The device of claim 3, wherein the disc is configured to rotate.

### Claim 5 (depends on 4)

The device of claim 4, wherein the disc is configured to deposit the sample of material from the first or second through hole into a sample collection container when the sample collector is moved.

### Claim 6 (depends on 1)

The device of claim 1, wherein the sample collector is configured to remove a sample of material that has accumulated in a passage formed in part by the first or second through hole.

### Claim 7 (depends on 1)

The device of claim 1, wherein the inlet and the first outlet are disposed along the flowpath between a source and a bulk collection container.

### Claim 8 (depends on 1)

The device of claim 1, wherein the sample collector is configured to move through the column of material and remove a slice of material from the column.

### Claim 9 (depends on 2)

The device of claim 2 wherein the sample collector is configured such that when the first through hole aligns with the first outlet the second through hole aligns with the second outlet.

### Claim 10 (depends on 1)

The device of claim 1, wherein the first outlet is configured to allow outflow to a first destination and the second outlet is configured to allow outflow to a second destination.