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US 9,035,027 B2Granted
Dual variable domain immunoglobulins and uses thereof
AssigneeAbbVie Inc.
InventorsTariq Ghayur, Peter C. Isakson, Lisa M. Olson, Chengbin Wu, Margaret Hugunin, Rajesh V. Kamath, Carolyn A. Cuff, Hamish J. Allen
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Abstract
The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.
Claims18
A binding protein capable of binding at least IL-1α and IL-1β, comprising first and second polypeptide chains, wherein said first polypeptide chain comprises a first VD1-(X1)n-VD2-C-(X2)n, wherein
- VD1 is a first heavy chain variable domain comprising CDRs 1-3 from SEQ ID NO:
- 52;
- VD2 is a second heavy chain variable domain comprising CDRs 1-3 from SEQ ID NO:
- 68;
- C is a heavy chain constant domain;
- X1 is a linker;
- X2 is an Fc region;
- and
- n is 1;
- and
- wherein said second polypeptide chain comprises a second VD1-(X1)n-VD2-C-(X2)n, wherein
- VD1 is a first light chain variable domain comprising CDRs 1-3 from SEQ ID NO:
- 53;
- VD2 is a second light chain variable domain comprising CDRs 1-3 from SEQ ID NO:
- 69;
- C is a light chain constant domain;
- X1 is a linker;
- n is 1 for (X1)n;
- and
- (X2)n is absent.
17 more elements
Dependencies are inferred from the claim text.