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US 9,034,925 B2Granted
L-ornithine phenyl acetate and methods of making thereof
AssigneeOcera Therapeutics, Inc.
InventorsKeith Anderson, Jim Behling, Christine Henderson Dougan, Stephen William Watt, Peter Manini, Attilia Figini
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Abstract
Disclosed herein are forms of L-ornithine phenyl acetate and methods of making the same. A crystalline form may, in some embodiments, be Forms I, II, III and V, or mixtures thereof. The crystalline forms may be formulated for treating subjects with liver disorders, such as hepatic encephalopathy. Accordingly, some embodiments include formulations and methods of administering L-ornithine phenyl acetate.
Claims22
A process for making L-ornithine phenyl acetate salt comprising:
- intermixing an L-ornithine salt, a benzoate salt and a solvent to form an intermediate solution;
- intermixing phenyl acetate with said intermediate solution;
- and
- isolating a composition comprising at least 70% crystalline L-ornithine phenyl acetate by weight.
1 more element
Dependencies are inferred from the claim text.