Acyl piperidine inhibitors of soluble epoxide hydrolase
AssigneeThe Regents of the University of California
InventorsBruce D. Hammock, Kin Sing Lee, Christophe Morisseau
Life of this patent
Estimating the term…
Abstract
Inhibitors of the soluble epoxide hydrolase (sEH) are provided that incorporate multiple pharmacophores and are useful in the treatment of diseases. In some embodiments, the present invention provides a method for monitoring the activity of a soluble epoxide hydrolase, the method including contacting the soluble epoxide hydrolase with an amount of a compound of the present invention sufficient to produce a detectable change in the fluorescence of the soluble epoxide hydrolase by interacting with one or more tryptophan residues present in the catalytic site of said sEH.
Claims9
A compound selected from the group consisting of 1-(1-(2-methylbutyryl)piperidin-4-yl)-3-(4-(trifluoromethoxy)phenyl)urea, (S)-1-(1-(2-methylbutanoyl)piperidin-4-yl)-3-(4-(trifluoromethyl)phenyl)urea, 1-(1-isobutyrylpiperidin-4-yl)-3-(4-(trifluoromethoxy)phenyl)urea, 1-(1-(2-ethylbutanoyl)piperidin-4-yl)-3-(4-(trifluoromethoxy)phenyl)urea, 1-(1-(2-ethylbutanoyl)piperidin-4-yl)-3-(4-(trifluoromethyl)phenyl)urea, (S)-1-(1-(2-methylbutanoyl)piperidin-4-yl)-3-(4-(trifluoromethyl)phenyl)urea, 1-cyclohexyl-3-(1-(2-methylbutanoyl)piperidin-4-yl)urea, 1-cycloheptyl-3-(1-(2-methylbutanoyl)piperidin-4-yl)urea, 1-(4-isopropylphenyl)-3-(1-(2-methyl butanoyl)piperidin-4-yl)urea, 1-(3,5-di-trifluoromethylphenyl)-3-(1-(2-methylbutanoyl)piperidin-4-yl)urea, 1-(4-tert-butylphenyl)-3-(1-(2-methyl butanoyl)piperidin-4-yl)urea, 1-(4-ethylcyclohexyl)-3-(1-isobutyrylpiperidin-4-yl)urea, or salts thereof.
Dependencies are inferred from the claim text.