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US 9,034,859 B2Granted
Sulfated oxysterol and oxysterol sulfation by hydroxysterol sulfotransferase promote lipid homeostasis and liver proliferation
AssigneeVirginia Commonwealth University
InventorShunlin Ren
Life of this patent
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Abstract
Methods and compositions for the prevention and treatment of liver damage or disease in a subject in need thereof are provided. The methods involve providing the sulfated oxysterol 25-hydroxycholesterol-3-sulfate (25HC3S) to the subject e.g. by 1) administering 25HC3S to the subject; or 2) overexpressing, in the subject, the hydroxysterol sulfotransferase enzyme SULT2B1b, which catalyzes the sulfation of 25-hydroxycholesterol (25HC) to form 25HC3S.
Claims11
A method for promoting liver cell proliferation or liver tissue regeneration in a subject, comprising:
- i) identifying a subject in need of at least one of liver cell proliferation and liver tissue regeneration, and
- ii) elevating a level of 25-hydroxycholesterol-3-sulfate (25HC3S) in said subject by administering to said subject a composition comprising
- 25HC3S and
- a physiologically compatible carrier,
- wherein said subject does not have hyperlipidemia, and wherein said elevating promotes proliferation of liver cells or regeneration of liver tissue in said subject.
2 more elements
Dependencies are inferred from the claim text.