Loading patent…
AssigneeKoninklijke Philips N.V.
InventorsHolger Gruell, Anke De Vries, Sander Langereis, Johan Lub, Erica M. G. Aussems-Custers
Estimating the term…
Described are amphiphilic polymers that are provided with chelating moieties. The amphiphilic polymers are block copolymers comprising a hydrophilic block and a hydrophobic block, with the chelating moieties linked to the end-group of the hydrophilic block. The disclosed polymers are capable of self-assembly into structures such as micelles and polymersomes. With suitable metals present in the form of coordination complexes with 5 the chelating moieties, the chelating amphiphilic polymers of the invention are suitable for use in various imaging techniques requiring metal labeling, such as MRI (T 1/T 2 weighted contrast agents or CEST contrast agents) SPECT, PET or Spectral CT.
A chelating amphiphilic polymer that is capable of self-assembly comprising a hydrophilic block and a hydrophobic block, wherein the hydrophilic block is provided with a chelating moiety selected from the group consisting of DOTA, DTPA, HYNIC, and desferoxamine as an end-group.
Dependencies are inferred from the claim text.