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US 9,029,508 B2Granted
Dual variable domain immunoglobulins and uses thereof
AssigneeAbbVie Inc.
InventorsTariq Ghayur, Susan E. Morgan-Lappe, Edward B. Reilly, Gillian A. Kingsbury, Andrew Phillips, Jieyi Wang, Randy L. Bell, Suzanne M. Norvell, Yingchun Li, Junjian Liu, Hua Ying
Life of this patent
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Abstract
The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.
Claims22
A binding protein comprising first and second polypeptide chains, each independently comprising VD1-(X1)n-VD2-C-(X2)n, wherein
- VD1 is a first variable domain;
- VD2 is a second variable domain;
- C is a constant domain;
- X1 is a linker;
- X2 is an Fc region;
- n is 0 or 1;
- wherein the VD1 domains on the first and second polypeptide chains form a first functional target binding site and the VD2 domains on the first and second polypeptide chains form a second functional target binding site, and wherein the binding protein is capable of binding VEGF and DLL4, wherein the first and second polypeptide chains of the binding protein comprise:
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86 more elements
Dependencies are inferred from the claim text.