Alpha (1,2) fucosyltransferases suitable for use in the production of fucosylated oligosaccharides
AssigneeGlycosyn LLC
InventorsMatthew Ian Heidtman, Massimo Merighi, John M. McCoy
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Abstract
The invention provides compositions and methods for engineering E. coli or other host production bacterial strains to produce fucosylated oligosaccharides, and the use thereof in the prevention or treatment of infection.
Claims18
A method for producing a fucosylated oligosaccharide in a bacterium comprising providing the bacterium comprising an exogenous lactose-utilizing α(1,2) fucosyltransferase enzyme, wherein an amino acid sequence of said enzyme comprises SEQ ID NO:8 and wherein said bacterium produces 2′fucosyllactose (2′-FL).
A method for producing a fucosylated oligosaccharide in a bacterium comprising providing the bacterium comprising an exogenous lactose-utilizing α(1,2) fucosyltransferase enzyme, wherein an amino acid sequence of said enzyme comprises SEQ ID NO:8 and wherein said fucosylated oligosaccharide comprises a fucose group linked to a galactose group through an alpha(1,2) linkage.
Dependencies are inferred from the claim text.