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US 9,023,897 B2Granted
Biodegradable drug delivery compositions
AssigneeMedincell
InventorGeorges Gaudriault
Life of this patent
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Abstract
A biodegradable drug delivery compositions comprising a triblock copolymer containing a polyester and a polyethylene glycol and a diblock copolymer containing a polyester and an end-capped polyethylene glycol, as well as a pharmaceutically active principle is disclosed.
Claims18
A biodegradable drug delivery composition comprising:
- (a) a biodegradable triblock copolymer having the formula:
- poly(lactic acid)v-poly(ethylene glycol)w,-poly(lactic acid)x
- wherein v and x are the number of repeat units ranging from 24 to 682 and w is the number of repeat units ranging from 4 to 273 and v=x or v≠x;
- (b) a biodegradable diblock copolymer having the formula:
- methoxy poly(ethylene glycol)y-poly(lactic acid)z,
- wherein y and z are the number of repeat units, with y ranging from 3 to 45 and z ranging from 7 to 327 wherein the ratio of the biodegradable triblock copolymer of (a) and the biodegradable diblock copolymer of (b) is 1:3 to 1:8 or 1:1 to 1:19 or 3:2 to 1:19 in said biodegradable drug composition, which is insoluble in an aqueous environment;
- and
- (c) at least one pharmaceutically active principle.
5 more elements
A biodegradable drug delivery composition comprising:
- (a) a biodegradable triblock copolymer present in an amount of 3.0% to 45% (w%/w%) of the total composition having the formula:
- poly(lactic acid)v-poly(ethylene glycol)w-poly(lactic acid)x
- wherein v and x are the number of repeat units ranging from 24 to 682 and w is the number of repeat units ranging, from 4 to 273 v and x being lactyl or lactoyl repeat units and w being ethylene glycol repeat units and v=x or v≠x;
- (b) a biodegradable diblock copolymer present in an amount of 8.0% to 50% (w%/w%) of the total composition having the formula:
- methoxy poly(ethylene glycol)y-poly(lactic acid)z
- wherein y and z are the number of repeat units y ranging from 3 to 45 and z ranging from 7 to 327, y being the number of ethylene glycol repeat units and z the number of lactyl or lactoyl repeat units wherein the ratio of the biodegradable triblock copolymer of (a) and the biodegradable diblock copolymer of (b) is 1:
- 3 to 1:8 or 1:1 to 1:19 or 3:2 to 1:19 in said biodegradable drug composition, which is insoluble in an aqueous environment;
- and (c) at least one pharmaceutically active principle present in an amount of 1% to 20% (w%/w%) of the total composition.
5 more elements
Dependencies are inferred from the claim text.