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US 9,023,338 B2Granted
Cancer stem cell antigen vaccines and methods
AssigneeCedars-Sinai Medical Center
InventorJohn S. Yu
Life of this patent
Estimating the term…
Abstract
Method of stimulating an immune response (e.g., to treat cancer) include administering to a patient a composition including dendritic cells that present cancer stem cell antigens. Compositions including cancer stem cell antigens are also provided herein.
Claims30
A method of treating a glioma in a patient, the method comprising:
- obtaining a population of dendritic cells;
- contacting the dendritic cells with one or more isolated peptides of CD133 under conditions such that the dendritic cells present the one or more isolated peptides of CD133, wherein the one or more isolated peptides of CD133 are peptides of 8 to 10 contiguous amino acid residues of amino acid residues 325-350 of SEQ ID NO:
- 53;
- and
- administering to the patient a composition comprising the dendritic cells.
2 more elements
A method of treating a glioma in a patient, the method comprising:
- administering to the patient a composition of dendritic cells that present CD133 peptides, wherein the CD133 peptides are peptides of 8 to 10 contiguous amino acid residues of amino acid residues 325-350of SEQ ID NO:53.
A method of treating a glioma in a patient, the method comprising:
- obtaining a population of dendritic cells;
- contacting the dendritic cells with one or more isolated peptides of CD133 under conditions such that the dendritic cells present the one or more isolated peptides of CD133, wherein the one or more isolated peptides of CD133 are peptides of 13 to 20 contiguous amino acid residues of amino acid residues 325-350 of SEQ ID NO:53;
- and
- administering to the patient a composition comprising the dendritic cells.
1 more element
A method of treating a glioma in a patient, the method comprising:
- administering to the patient a composition of dendritic cells that present CD133 peptides, wherein the CD133 peptides are peptides of 13 to 20 contiguous amino acid residues of amino acid residues 325-350 of SEQ ID NO:53.
Dependencies are inferred from the claim text.