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AssigneesBoehringer Ingelheim International GmbH, Vitae Pharmaceuticals, Inc.
InventorsYuri Bukhtiyarov, Salvacion Cacatian, Lawrence Wayne Dillard, Klaus Fuchs, Lanqi Jia, Deepak S. Lala, Angel Morales-Ramos, Suresh B. Singh, Shankar Venkatraman, Zhenrong Xu, Jing Yuan, Yi Zhao, Yajun Zheng, Cornelia Dorner-Ciossek, Ulrike Gross, Niklas Heine, Achim Sauer
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The present invention relates to spirocyclic acylguanidines and their use as inhibitors of the β-secretase enzyme (BACE1) activity, pharmaceutical compositions containing the same, and methods of using the same as therapeutic agents in the treatment of neurodegenerative disorders, disorders characterized by cognitive decline, cognitive impairment, dementia and diseases characterized by production of β-amyloid aggregates.
A compound represented by a structural formula selected from:
A method of treating a BACE1 mediated disorder or disease in a subject, comprising administering to the subject an effective amount of a compound represented by a structural formula selected from:
A compound selected from the group consisting of:
A compound represented by the following structural formula:
A compound represented by the following structural formula:
A compound represented by the following structural formula:
A compound represented by the following structural formula:
A compound represented by the following structural formula:
A compound represented by the following structural formula:
A compound represented by the following structural formula:
A compound represented by the following structural formula:
A compound represented by the following structural formula:
A compound represented by the following structural formula:
A compound represented by the following structural formula:
A compound represented by the following structural formula:
A compound represented by the following structural formula:
A compound represented by the following structural formula:
A compound represented by the following structural formula:
A compound represented by the following structural formula:
Dependencies are inferred from the claim text.