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US 9,012,662 B2Granted
Intermediates for the preparation of lubiprostone
AssigneeScinoPharm (Kunshan) Biochemical Technology Co., Ltd.
InventorsJulian Paul Henschke, Yuanlian Liu, Lizhen Xia, Yung-Fa Chen
Life of this patent
Estimating the term…
Abstract
Intermediates of the following formulae for the preparation of lubiprostone:
Claims2
A compound of formula (9) (isopropyl 7-((1R,2R,3R)-3-(tert-butyldimethylsilyloxy)-2-(4,4-difluoro-3-oxooctyl)-5-oxocyclopentyl)heptanoate):
A compound of formula (7) ((Z)-isopropyl 7-((1R,2R,3R)-2-((1E,5E)-3-(benzyloxy)-4,4-difluoroocta-1,5-dienyl)-3-(tert-butyldimethylsilyloxy)-5-oxocyclopentyl)hept-5-enoate):
Dependencies are inferred from the claim text.