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US 9,011,847 B2Granted
Anti-FAP antibodies and methods of use
AssigneeRoche Glycart AG
InventorsMarina Bacac, Anne Freimoser-Grundschober, Ralf Hosse, Christian Klein, Ekkehard Moessner, Valeria G. Nicolini, Pablo Umaña
Life of this patent
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Abstract
The invention provides antibodies against Fibroblast Activation Protein (FAP) and methods of using the same.
Claims26
An antibody that specifically binds to Fibroblast Activation Protein (FAP), wherein said antibody comprises a
- (a) heavy chain CDR1 comprising an amino acid sequence selected from the group consisting of SEQ ID NO:
- 3, SEQ ID NO:
- 13, and SEQ ID NO:
- 23;
- (b) heavy chain CDR2 comprising an amino acid sequence selected from the group consisting of SEQ ID NO:
- 47, SEQ ID NO:
- 81, and SEQ ID NO:
- 113;
- (c) heavy chain CDR3 comprising the amino acid sequence of SEQ ID NO:
- 135;
- (d) light chain CDR3 comprising the amino acid sequence of SEQ ID NO:
- 143;
- (e) light chain CDR2 comprising the amino acid sequence of SEQ ID NO:
- 151and;
- (f) light chain CDR3 comprising the amino acid sequence of SEQ ID NO:
- 163.
13 more elements
Dependencies are inferred from the claim text.