Implantable medical device including a protection/retaining layer for an active ingredient or drug, in particular a water-soluble one

An implantable medical device to be implanted at a site of implantation, comprising at least one therapeutically active agent or medicament, comprising:

• receiving means for receiving at least a layer consisting essentially of said active agent or medicament in the form of a solid deposit;
• and
• at least one biocompatible and biodegradable protecting/retaining layer for protecting the active agent or medicament until it is at its site of implantation, said biocompatible and biodegradable protecting/retaining layer comprising at least one biocompatible and biodegradable film-forming agent and at least one hydrophobic, biocompatible, agent for controlling the disintegration rate of the protecting/retaining layer, wherein the active agent or medicament is water-soluble and comprises an NO precursor agent in the form of a solid deposit.

An implantable medical device to be implanted at a site of implantation, comprising at least one therapeutically active agent or medicament, comprising receiving means for receiving at least a layer consisting essentially of said active agent or medicament, in the form of a solid deposit;

• and least one biocompatible and biodegradable protecting/retaining layer for protecting the active agent or medicament until it is at its site of implantation, said biocompatible and biodegradable protecting/retaining layer comprising at least one biocompatible and biodegradable film-forming agent selected from a polyalkylene glycol, a polyvinylpyrrolidone and mixtures thereof in any proportions, and at least one hydrophobic, biocompatible, agent in an amount sufficient to control the disintegration rate of the protecting/retaining layer comprising a dexamethasone component selected from dexamethasone, dexamethasone phosphate, disodium salt of dexamethasone phosphate, dexamethasone acetate, and any mixture thereof.

An implantable medical device to be implanted at a site of implantation, comprising at least one therapeutically active agent or medicament, comprising receiving means for receiving at least a layer consisting essentially of said active agent or medicament, in the form of a solid deposits and at least one biocompatible and biodegradable protecting/retaining layer for protecting the active agent or medicament until it is at its site of implantation, said biocompatible and biodegradable protecting/retaining layer comprising from 60% to 30% by weight of at least one biocompatible and biodegradable film-forming agent and from 40% to 70% by weight of at least one hydrophobic, biocompatible, agent for controlling the disintegration rate of the protecting/retaining layer.

An implantable medical device to be implanted at a site of implantation, comprising at least one therapeutically active agent or medicament, comprising receiving means for receiving at least a layer consisting essentially of said active agent or medicament, in the form of a solid deposit;

• and at least one biocompatible and biodegradable protecting/retaining layer for protecting the active agent or medicament until it is at its site of implantation, said biocompatible and biodegradable protecting/retaining layer comprising from 80% to 30% by weight of at least one biocompatible and biodegradable film-forming agent and from 20% to 70% by weight of at least one hydrophobic, biocompatible, agent for controlling the disintegration rate of the protecting/retaining layer.