Amine-containing lipids and uses thereof

A compound of formula:

• or a salt thereof;
• wherein:
• each occurrence of x is an integer between 1 and 10, inclusive;
• y is an integer between 1 and 10, inclusive;
• each occurrence of R7 is independently hydrogen or —CH2CH2C(═O)R1;
• wherein at least one of R7 is —CH2CH2C(═O)R1;
• each occurrence of R1 is independently cyclic or acyclic, substituted or unsubstituted, branched or unbranched aliphatic;
• substituted or unsubstituted aryl;
• substituted or unsubstituted heteroaryl;
• —ORA;
• —SRA;
• or —NHRA;
• wherein each occurrence of RA is independently cyclic or acyclic, substituted or unsubstituted, branched or unbranched C9-C16 aliphatic;
• substituted or unsubstituted aryl;
• or substituted or unsubstituted heteroaryl;
• wherein each instance of substituted refers to the replacement of one, two, three, or more of the hydrogen atoms of an aliphatic, heteroaliphatic, aryl, or heteroaryl group with one, two, three, or more substituents independently selected from the group consisting of aliphatic;
• heteroaliphatic;
• aryl;
• heteroaryl;
• arylalkyl;
• heteroarylalkyl;
• alkoxy;
• aryloxy;
• heteroalkoxy;
• heteroaryloxy;
• alkylthio;
• arylthio;
• heteroalkylthio;
• heteroarylthio;
• —F;
• —Cl;
• —Br;
• —I;
• —OH;
• —NO2;
• —CN;
• —CF3;
• —CH2CF3;
• —CHCl2;
• —CH2OH;
• —CH2CH2OH;
• —CH2NH2;
• —CH2SO2CH3;
• —C(O)Rx;
• —CO2(Rx);
• —OC(O)Rx;
• —OCO2Rx;
• —OCON(Rx)2;
• —N(Rx)2;
• —S(O)2Rx;
• and —NRx(CO)Rx, wherein each occurrence of Rx independently is selected from the group consisting of aliphatic, heteroaliphatic, aryl, heteroaryl, arylalkyl, and heteroarylalkyl.

A compound of the formula:

• or a salt thereof;
• wherein:
• A is acyclic, substituted or unsubstituted, branched or unbranched heteroaliphatic;
• V is C═O;
• R1 is cyclic or acyclic, substituted or unsubstituted, branched or unbranched aliphatic;
• substituted or unsubstituted aryl;
• substituted or unsubstituted heteroaryl;
• —SRA;
• and —NHRA;
• wherein each occurrence of RA is independently cyclic or acyclic, substituted or unsubstituted, branched or unbranched C9-C16 aliphatic;
• substituted or unsubstituted aryl;
• or substituted or unsubstituted heteroaryl;
• R2 is cyclic or acyclic, substituted or unsubstituted, branched or unbranched aliphatic;
• substituted or unsubstituted aryl;
• substituted or unsubstituted heteroaryl;
• —SRB;
• or —NHRB;
• wherein each occurrence of RB is independently a cyclic or acyclic, substituted or unsubstituted, branched or unbranched C9-C16 aliphatic;
• substituted or unsubstituted aryl;
• or substituted or unsubstituted heteroaryl;
• R3 is hydrogen;
• halogen;
• cyclic or acyclic, substituted or unsubstituted, branched or unbranched aliphatic;
• cyclic or acyclic, substituted or unsubstituted, branched or unbranched heteroaliphatic;
• substituted or unsubstituted aryl;
• substituted or unsubstituted heteroaryl;
• —ORC;
• —C(═O)RC;
• —CO2RC;
• —CN;
• —SCN;
• —SRC;
• —SORC;
• —NO2;
• —N3;
• —N(RC)2;
• —NHC(═O)RC;
• —NRCC(═O)N(RC)2;
• —OC(═O)ORC;
• —OC(═O)Rc;
• —OC(═O)N(RC)2;
• —NRCC(═O)ORC;
• or —C(RC)3;
• wherein each occurrence of RC is independently a hydrogen;
• a protecting group;
• halogen;
• cyclic or acyclic, substituted or unsubstituted, branched or unbranched aliphatic;
• cyclic or acyclic, substituted or unsubstituted, branched or unbranched heteroaliphatic;
• substituted or unsubstituted aryl;
• or substituted or unsubstituted heteroaryl;
• R4 is hydrogen;
• halogen;
• cyclic or acyclic, substituted or unsubstituted, branched or unbranched aliphatic;
• cyclic or acyclic, substituted or unsubstituted, branched or unbranched heteroaliphatic;
• substituted or unsubstituted aryl;
• substituted or unsubstituted heteroaryl;
• —ORD;
• —C(═O)RD;
• —CO2RD;
• —CN;
• —SCN;
• —SRD;
• —SORD;
• —SO2RD;
• —NO2;
• —N3;
• —N(RD)2;
• —NHC(═O)RD;
• —NRCC(═O)N(RD)2;
• —OC(═O)ORD;
• —OC(═O)RD;
• —OC(═O)N(RD)2;
• —NRCC(═O)ORD;
• or —C(RD)3;
• wherein each occurrence of RD is independently a hydrogen;
• a protecting group;
• halogen;
• cyclic or acyclic, substituted or unsubstituted, branched or unbranched aliphatic;
• cyclic or acyclic, substituted or unsubstituted, branched or unbranched heteroaliphatic;
• substituted or unsubstituted aryl;
• or substituted or unsubstituted heteroaryl;
• provided that at least one of R3 and R4 is a substituted aliphatic;
• wherein each instance of substituted refers to the replacement of one, two, three, or more of the hydrogen atoms of an aliphatic, heteroaliphatic, aryl, or heteroaryl group with one, two, three, or more substituents independently selected from the group consisting of aliphatic;
• heteroaliphatic;
• aryl;
• heteroaryl;
• arylalkyl;
• heteroarylalkyl;
• alkoxy;
• aryloxy;
• heteroalkoxy;
• heteroaryloxy;
• alkylthio;
• arylthio;
• heteroalkylthio;
• heteroarylthio;
• —F;
• —Cl;
• —Br;
• —I;
• —OH;
• —NO2;
• —CN;
• —CF3;
• —CH2CF3;
• —CHCl2;
• —CH2OH;
• —CH2CH2OH;
• —CH2NH2;
• —CH2SO2CH3;
• —C(O)Rx;
• —CO2(Rx);
• —OC(O)Rx;
• —OCO2Rx;
• —OCON(Rx)2;
• —N(Rx)2;
• —S(O)2Rx;
• and —NRx(CO)Rx, wherein each occurrence of Rx independently is selected from the group consisting of aliphatic, heteroaliphatic, aryl, heteroaryl, arylalkyl, and heteroarylalkyl.