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US 9,006,230 B2Granted
1,6-diazabicyclo [3,2,1] octan-7-one derivatives and their use in the treatment of bacterial infections
AssigneeWockhardt Limited
InventorsSachin Bhagwat, Prasad Keshav Deshpande, Satish Bhawsar, Vijaykumar Jagdishwar Patil, Ravikumar Tadiparthi, Shivaji Sampatrao Pawar, Sunil Bhaginath Jadhav, Sanjay Kisan Dabhade, Vikas Vitthalrao Deshmukh, Bharat Dond, Satish Birajdar, Mohammad Usman Shaikh, Deepak Dekhane, Piyush Ambalal Patel
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Abstract
Compounds of Formula (I), their preparation and use in preventing or treating bacterial infections are disclosed.
Claims15
A compound of Formula (I)
- or a stereoisomer or a pharmaceutically acceptable salt thereof;
- wherein:
- Q is heteroaryl selected from oxadiazole, thiadiazole, or tetrazole;
- R1 is:
- (a) hydrogen,
- (b) (CO)n—R3, or
- (c) COOR4,
- n is 0 or 1;
- R2 is
- SO3M;
- M is hydrogen or a cation;
- R3 is:
- (a) hydrogen,
- (b) C1-C6 alkyl optionally substituted with one or more substituents independently selected from halogen, OR5, CN, COOR5, CONR6R7, NR6R7, NR5COR8, NR5CONR6R7, heterocyclyl, heteroaryl, cycloalkyl or aryl,
- (d) NR6R7,
- (e) CONR6R7,
- (g) aryl optionally substituted with one or more substituents independently selected from C1-C6 alkyl, OR5, NR6R7, halogen, CN, CONR6R7, SO2-alkyl, SO2-aryl, OSO2-alkyl, OSO2-aryl, or NHCONR6R7,
- (h) heterocyclyl optionally substituted with one or more substituents independently selected from C1-C6 alkyl, OR5, NR6R7, halogen, CN, CONR6R7, SO2-alkyl, SO2-aryl, OSO2-alkyl, OSO2-aryl, or NHCONR6R7,
- (i) heteroaryl optionally substituted with one or more substituents independently selected from C1-C6 alkyl, OR5, NR6R7, halogen, CN, CONR6R7, SO2-alkyl, SO2-aryl, OSO2-alkyl, OSO2-aryl, or NHCONR6R7,
- (l) OR8;
- R4 is:
- (a) hydrogen, or
- (b) C1-C6 alkyl optionally substituted with one or more substituents independently selected from halogen, OR5, CN, COOR5, CONR6R7, NR6R7, NR5COR8, heterocyclyl, heteroaryl, cycloalkyl or aryl;
- R5 and R8 are each independently:
- (a) hydrogen, or
- (b) C1-C6 alkyl optionally substituted with one or more substituents independently selected from halogen, CN, CONR6R7, NR6R7, heterocyclyl, heteroaryl, cycloalkyl or aryl;
- R6 and R7 are each independently:
- (a) hydrogen, or
- (b) C1-C6 alkyl optionally substituted with one or more substituents independently selected from halogen, OR5, CN, COOR5, CONR5R8, NR5R8, NR5COR8, heterocyclyl, heteroaryl, cycloalkyl or aryl.
26 more elements
Dependencies are inferred from the claim text.