# US 9,006,206 B2 · Composition and methods for modulating cell proliferation and cell death

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- Number: US 9,006,206 B2
- Document ID: US9006206B2
- Status: Granted
- Kind: B2
- Application number: 14/280,822
- Filed: 2014-05-19
- Published: 2014-09-11
- Granted: 2015-04-14
- Earliest claimed: 2007-02-27
- Assignees: Rosetta Genomics Ltd.; Yeda Research and Development Co. Ltd.
- Applicants: Rosetta Genomics, Ltd.; Yeda Research and Development Company Ltd.
- Inventors: Moshe Oren; Nina Raver-Shapira; Efi Marciano; Yael Spector
- Web page: https://patentgrep.com/patent/US9006206B2

## CPC

- C12Q 1/6886: for cancer (immunoassay for cancer G01N33/575)
- A61K 31/7105: Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
- A61K 45/06: Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- C12N 15/1135: {against oncogenes or tumor suppressor genes}
- C12N 2310/113: targeting other non-coding nucleic acids, e.g. antagomirs
- C12N 2310/141: MicroRNAs, miRNAs
- C12Q 2600/158: Expression markers
- C12Q 2600/178: miRNA, siRNA or ncRNA
- C12Q: MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS (immunoassay G01N33/53); COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- C12N: MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA (microbiological testing media C12Q1/00)

## Abstract

Described herein are compositions and methods for modulation of p53-dependent cell death and cell proliferation. The compositions are microRNAs and associated nucleic acids.

## Claims

### Claim 1

A method of treating a cancer associated with the p53 gene in a subject, comprising administering to a subject in need thereof an effective amount of a composition comprising a nucleic acid, wherein the nucleic acid comprises SEQ ID NO: 1or a sequence at least about 80% identical to SEQ ID NO: 1.

### Claim 2 (depends on 1)

The method of claim 1, wherein the composition is administered in combination with at least one other anticancer agent in unit dosage form.

### Claim 3 (depends on 1)

The method of claim 1, wherein said cancer is p53 negative.

### Claim 4

A method of inducing tumor cell death or inhibiting tumor cell proliferation in a subject, comprising administering to a subject in need thereof a therapeutically effective amount of a composition comprising a nucleic acid, wherein the nucleic acid comprises SEQ ID NO: 1 or a sequence at least about 80% identical to SEQ ID NO: 1.

### Claim 5 (depends on 4)

The method of claim 4, wherein said tumor cells are p53 negative.