# US 9,005,678 B1 · Pharmaceutical composition for treating cancer and use thereof

> Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt

- Number: US 9,005,678 B1
- Document ID: US9005678B1
- Status: Granted
- Kind: B1
- Application number: 14/250,914
- Filed: 2014-04-11
- Granted: 2015-04-14
- Earliest claimed: 2013-11-26
- Assignees: Jiangsu Province Institute of Traditional Chinese Medicine
- Applicants: Jiangsu Province Institute of Traditional Chinese Medicine
- Inventors: Peng Cao; Xiaolan Cheng; Jiege Huo; Xiaoning Wang; Jingqing Hu; Xueting Cai; Yang Yang; Chunping Hu; Guoli Wei
- Web page: https://patentgrep.com/patent/US9005678B1

## CPC

- A61K 36/9068: Zingiber, e.g. garden ginger
- A61K 31/555: containing heavy metals, e.g. hemin, hematin, melarsoprol
- A61K 36/481: Astragalus (milkvetch)
- A61K 36/54: Lauraceae (Laurel family), e.g. cinnamon or sassafras
- A61K 36/65: Paeoniaceae (Peony family), e.g. Chinese peony
- A61K 36/725: Ziziphus, e.g. jujube
- A61P 35/00: Antineoplastic agents
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

The present invention discloses a pharmaceutical composition for treating cancer, comprising: (1) a herbal composition generated from Astragali membranaceus radix, Cinnamomi cortex, Paeonia alba radix, Jujubae fructus, and Zingiberis rhizoma or an extract of the above mixed herbal medicine; (2) one or more chemotherapeutic compounds. The present invention also discloses use of the above pharmaceutical composition in the preparation of medicament for treating human cancer and in the preparation of medicament for reducing side effects of chemotherapeutic compounds in human body. The pharmaceutical composition of the present invention can reduce chemotherapy-induced peripheral neuropathic side effects such as limb paresthesia, pain, cold skin, formication, powerlessness and the like, increase tolerance dosages of anticancer drugs, and enhance efficacy of anticancer drugs.

## Claims

### Claim 1

A composition consisting essentially of Astragali membranaceus radix extract, Cinnamomi cortex extract, Paeonia alba radix extract, Jujubae fructus extract, and Zingiberis rhizome extract and a component selected from the group consisting of oxaliplatin, cisplatin, carboplatin, taxol, vincristine, and vinblastine.