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US 9,005,629 B2Granted
Method for treating cancer with an antibody to CD223 protein
AssigneesSt. Jude Children's Research Hospital, The Johns Hopkins University
InventorsDrew M Pardoll, Ching-Tai Huang, Jonathan Powell, Charles Drake, Dario A Vignali, Creg J Workman
Life of this patent
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Abstract
Mammals with cancer are treated with an antibody which specifically binds to CD223 protein and inhibits negative T cell regulatory function of CD223. The mammal may be a human. The antibody may be a monoclonal antibody. The amount of the antibody administered may be sufficient to enhance an immune T cell response to the cancer.
Claims4
A method for treating a mammal with a cancer, comprising:
- administering to the mammal an antibody which specifically binds to CD223 protein and inhibits negative T cell regulatory function of CD223.
Dependencies are inferred from the claim text.