System for the detection of gamma radiation from a radioactive analyte

A system for the ex vivo real-time detection of gamma radiation emitted by a subject from systemic administration and uptake of a radioactive analyte that decays in vivo over a period of time by positron emission, the system comprising:

• at least one ex vivo measurement sensor having a sensor housing, a scintillation material, a light detector, a temperature sensor, a signal amplifier, a sensor processor, a non-transient sensor memory, and a sensor power supply,
• the light detector, temperature sensor, signal amplifier, sensor processor, sensor memory, and sensor power supply in operable communication,
• the scintillation material and light detector disposed within the sensor housing with the scintillation material adapted to receive a level of gamma radiation over the period of time from the in vivo radioactive analyte and to emit photons representative of the gamma radiation level, the light detector disposed with respect to the scintillation material so as to be adapted to receive and convert the multiplied photons into signal data representative of the frequency level over time of gamma radiation received,
• the signal amplifier adapted to amplify the signal data, the sensor memory including a measurement sensor identifier, the measurement sensor having at least one sensor output port for such amplified signal data;
• a measurement control device having a control processor, a non-transient control memory, a control power supply, and a clock,
• the control processor, control memory, control power supply, and clock in operable communication,
• the measurement control device having a control input port operably engaged with the sensor output port and adapted to receive amplified signal data from the measurement sensor;
• wherein the control memory includes control computer program code executable by the control processor, the control computer program code including a first module for measurement, a second module for data management;
• wherein the first module is adapted to receive the measurement sensor identifier, the signal data, and a subject identifier and to associate the signal data, sensor identifier, and measurement sensor identifier in a record file format;
• a temperature compensator coupled with the temperature sensor, the temperature sensor adapted to measure an ambient temperature with the system adapted to communicate the ambient temperature to the temperature compensator, such that the temperature compensator is adapted to generate a temperature correction factor based on comparison of the ambient temperature to a reference temperature, the temperature compensator further adapted to apply the temperature correction factor to the signal data to produce temperature compensated signal data;
• wherein the second module is adapted to receive the signal data of a record file from the first module and to transmit the compensated signal data to a desired storage;
• a processing station in communication with the measurement control device, the station having a station processor, a non-transient station memory, a station power supply, the station processor, station memory, station power supply in operable communication, the processing station having a station input port operably engaged with the control output port and adapted to receive data from the measurement control device;
• wherein the station memory includes station computer program code executable by the station processor, the station computer program code including a third module adapted to receive stored data of a record file from the second module, to apply such stored data to a predictive model to generate predictive data values over a desired period for such record file as a predictive outcome.

A system for the real-time detection of gamma radiation emitted by a subject from systemic administration and uptake of a radioactive analyte that decays by positron emission over a period of time, the system comprising:

• at least one in vivo measurement sensor having a hermetically sealed sensor housing of biocompatible material, a scintillation material, a light detector, a signal amplifier, a sensor processor, a non-transient sensor memory, and a sensor power supply,
• the light detector, signal amplifier, sensor processor, sensor memory, and sensor power supply in operable communication,
• the light detector having an active area and the scintillation material is configured to substantially match the active area, the scintillation material and light detector disposed within the sensor housing with the scintillation material adapted to receive a level of gamma radiation over the period of time from the in vivo radioactive analyte and to emit photons representative of the gamma radiation level, the light detector disposed with respect to the scintillation material so as to be adapted to receive and convert the multiplied photons into signal data representative of the frequency level over time of gamma radiation received,
• the signal amplifier adapted to amplify the signal data, the sensor memory including a measurement sensor identifier, the measurement sensor having at least one wireless sensor output port for such amplified signal data;
• an ex vivo measurement control device having a control processor, a non-transient control memory, a control power supply, and a clock,
• the control processor, control memory, control power supply, and clock in operable communication,
• the measurement control device having a wireless control input port operably engaged with the wireless sensor output port and adapted to receive amplified signal data from the measurement sensor;
• wherein the control memory includes control computer program code executable by the control processor, the control computer program code including a first module for measurement, a second module for data management;
• wherein the first module is adapted to receive the measurement sensor identifier, the amplified signal data, and a subject identifier and to associate the signal data, sensor identifier, and measurement sensor identifier in a record file format;
• wherein the second module is adapted to receive the amplified signal data of a record file from the first module and to transmit the amplified signal data to a desired storage;
• and
• a third module, wherein the third module is adapted to receive stored data of a record file from the second module, to apply such stored data to a predictive model to generate predictive data values over a desired period for such record file as a predictive outcome, and to transmit such predictive outcome to a desired storage.