Compounds with (1E, 6E)-1,7-bis-(3,4-dimethoxyphenyl)-4,4-disubstituted-hepta-1,6-diene-3,5-dione structural scaffold, their biological activity, and uses thereof

A pharmaceutical composition for treating a subject suffering from an androgen receptor associated medical condition, comprising:

• a compound according to formula VII:
• Wherein R1 and R2 are mono- or di-substituted groups, a methoxy group (—OCH3), a hydroxyl group (—OH), an alkyl sulfonyl group, or —OSO2C2H5;
• R1 and R2 could be the same or different;
• L is a carbonyl, alkylene, alkenylene, or alkynl when Z is not present;
• Z is —H, —OH, a substituted styrenyl, an aromatic ring, a cycloalkyl, —COR3, —CONR3R4, or —CX3, wherein R3 and R4 are each -c or a heterocyclic, or a heteroaryl moiety, or R3 and R4 together to form a heterocyclic ring, a morphorine;
• or Z is COOR, wherein R is —H, —CH3, —CnH2n+1, (n=2-4), or a cycloalkyl, when Y is not H;
• X is —F, —Cl, or —Br;
• Y is H when L is an alkylene, —CH2, and Z is —CONR3R4, R3 and R4 are each —H and a hetrocyclic or a heteroaryl, or a cycloalkyl, a cyclopentanyl;
• or Y is a short alkyl (C1-3), a methyl (—CH3), or —F, Cl, Br
• further wherein said pharmaceutical composition treats said subject suffering from said androgen receptor associated medical condition.