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US 9,000,210 B2Granted
Preparation of substituted 2-fluoroacrylic acid derivatives
AssigneeSaltigo GmbH
InventorsMichael Kreis, Jan Kirchhoff
Life of this patent
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Abstract
The present invention relates to a process for the preparation of substituted 2-fluoroacrylic acid derivatives.
Claims14
A process for the preparation of compounds of the formula (I),
- wherein R1 and R2 are identical or different and are, independently of one another, hydrogen, C1-C15-alkyl, (C6-C24-aryl or C1-C15-alkoxy, and R3 is C1-C15alkoxy, the process comprising:
- reacting compounds of the formula (II),
- wherein R1, R2 and R3 have the abovementioned meanings, and X is Cl, Br, I or a pseudohalogen, in the presence of:
- at least one base,
- a high-boiling-point polar aprotic solvent selected from the group consisting of ethylene glycol dibutyl ether, diethylene glycol dimethyl ether, tetraethylene glycol dimethylether, dimethylformamide, dimethyl sulfoxide, sulfolane, ortho-dichlorobenzene, N-methylpyrrolidone, and mixtures thereof, and
- at least one polymerization inhibitor selected from the group of 2,2,6,6-tetramethylpiperidine N-oxyl, sulfur, p-benzoquinone, 4-tert-butylcatechol, phenothiazine, di-tert-butylhydroxytoluene (BHT) and mixtures thereof.
3 more elements
A process for the preparation of compounds of the formula (I),
- wherein R1 and R2 are identical or different and are, independently of one another, hydrogen, C1-C15-alkyl, C6-C24-aryl or C1-C15-alkoxy, and R3 is C1-C15alkoxy, the process comprising:
- reacting compounds of the formula (II),
- wherein R1, R2 and R3 have the abovementioned meanings, and X is Cl, Br, I or a pseudohalogen, in the presence of:
- at least one base,
- a high-boiling-point polar aprotic solvent, and
- at least one polymerization inhibitor selected from the group of 2,2,6,6-tetramethylpiperidine N-oxyl, sulfur, p-benzoquinone, 4-tert-butylcatechol, phenothiazine, di-tert-butylhydroxytoluene (BHT) and mixtures thereof.
3 more elements
Dependencies are inferred from the claim text.