Back to results
US 9,000,208 B2Granted
Glutamate derivatives or salts thereof
AssigneeAjinomoto Co., Inc.
InventorsMasayuki Sugiki, Toru Okamatsu
Life of this patent
Estimating the term…
Abstract
Compounds having an excellent CaSR agonist activity are in demand. The invention provides glutamate derivatives or salts thereof, pharmaceutical compositions comprising the glutamate derivatives, preventive or therapeutic agents for diarrhea, hyperparathyroidism or peptic ulcer.
Claims18
A glutamate compound represented by formula (I):
- wherein:
- R1, R2, R3, R4 and R5 each independently represents a group selected from hydrogen atom, a halogeno group, hydroxyl group, nitro group, amino group, a C1-6 alkyl group which may have a substituent(s), a C1-6 alkoxy group which may have a substituent(s), a mono- or di-C1-6 alkylamino group which may have a substituent(s), sulfo group, and a group:
- provided that at least one of R1, R2 and R3 is sulfo group or a group selected from:
- R6 is hydrogen atom, hydroxyl group or a C1-6 alkyl group which may have a substituent(s);
- R7 is hydrogen atom or a C1-6 alkyl group which may have a substituent(s);
- X is methylene group or oxygen atom;
- and,
- E is a C1-6 alkoxy group which may have a substituent(s), a mercapto group which may have a substituent(s), or a group:
- wherein in formula (IIb), Z represents a divalent C1-6 hydrocarbon group which may have a substituent(s) and E2 represents hydrogen atom or a C1-6 alkyl group;
- provided that:
- when E is methoxy group, ethoxy group or benzyloxy group and X is methylene group, in a group:
- R7 is not methyl group, ethyl group or benzyl group:
- and,
- when E is butoxy group and X is methylene group, in a group:
- R7 does not represent a group:
- or a pharmaceutically acceptable salt thereof.
13 more elements
A glutamate compound represented by formula (I):
- wherein:
- R1, R2, R3, R4 and R5 each independently represents a group selected from hydrogen atom, a halogeno group, hydroxyl group, nitro group, amino group, a C1-6 alkyl group which may have a substituent(s), a C1-6 alkoxy group which may have a substituent(s) or a mono- or di-C1-6 alkylamino group which may have a substituent(s), sulfo group, and a group:
- provided that at least one of R1, R2 and R3 is sulfo group or a group selected from:
- R6 is hydrogen atom, hydroxyl group or a C1-6 alkyl group which may have a substituent(s);
- R7 is hydrogen atom or a C1-6 alkyl group which may have a substituent(s);
- X is methylene group or oxygen atom;
- and,
- E is a C1-6 alkoxy group which may have a substituent(s), a mercapto group which may have a substituent(s), or a group;
- wherein in formula (IIb), Z represents a divalent C1-6 hydrocarbon group which may have a substituent(s) and E2 represents hydrogen atom or a C1-6 alkyl group;
- provided that:
- (i) when X is methylene group, R3 is a carboxylic acid group and R1, R2, R4, R5 and R6 are hydrogen atom, then, E is not methoxy group;
- (ii) when X is methylene group, R2 is a carboxylic acid group, R5 is fluorine atom and R1, R3, R4 and R6 are hydrogen atom, then, E is not methoxy group;
- and,
- (iii) when E is methoxy group, ethoxy group or benzyloxy group and X is methylene group, then, in a group:
- R7 is not methyl group, ethyl group or benzyl group;
- and,
- when E is butoxy group and X is methylene group, in a group:
- R7 is not a group:
- or a pharmaceutically acceptable salt thereof.
16 more elements
Dependencies are inferred from the claim text.