Process for obtaining olopatadine and intermediates
AssigneeCrystal Pharma, S.A.U.
InventorsLuis Octavio Silva Guisasola, Lydia Mateos Burón, Antonio Lorente Bonde-Larsen, Luis Gerardo Gutiérrez Fuentes
Life of this patent
Estimating the term…
Loading patent…
AssigneeCrystal Pharma, S.A.U.
InventorsLuis Octavio Silva Guisasola, Lydia Mateos Burón, Antonio Lorente Bonde-Larsen, Luis Gerardo Gutiérrez Fuentes
Estimating the term…
Olopatadine can be obtained by means of a process comprising hydrolysis of a compound of general formula (II), wherein Y is OR1, wherein R1 is C1-C7 alkyl, C3-C7 cycloalkyl, aryl, arylalkyl, or heterocycle; or NR2R3, wherein R2 and R3, independently from each other, are C1-C7 alkyl, aryl, arylalkyl, or R2 and R3 together with the nitrogen atom to which they are bound form a heterocycle of 3 to 7 members, obtained by means of a process comprising reacting the corresponding ester or amide of 6,11-dihydro-11-oxodibenz[b,e]oxepin-2-acetic acid with a suitable Wittig reagent, in the presence of a base in a reaction medium comprising an organic solvent.
A process for obtaining a compound of general formula (II)
A process for obtaining (Z)-11-(3-dimethylaminopropylidene)-6,11-dihydrodibenz[b,e]oxepin-2-acetic acid isopropyl ester of formula (IIa)
A compound selected from the group consisting of:
Dependencies are inferred from the claim text.