Mangromicin compound and production method therefor
AssigneeThe Kitasato Institute
InventorsSatoshi Omura, Yoko Takahashi, Takuji Nakashima, Kazuhiko Otoguro, Kazuro Shiomi, Masato Iwatsuki, Atsuko Matsumoto
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Abstract
The present invention addresses the problem of providing an anti-trypanosomal drug having a novel skeleton, in order to solve issues that occur with conventional technologies. The present invention is based on the discovery of a microbe that produces an anti-trypanosomal drug having a novel skeleton. Specifically, this invention provides: a compound indicated by formula (I) having a trypanosomal inhibitory activity; an analog thereof; a production method therefor; and a Lechevalieria sp. K10-0216 strain that produces said compound.
Claims5
A compound represented by the following formula I
- wherein the compound has a molecular weight of 410, a molecular formula of C22H34O7, an infrared absorption maximum at 3440 and 1637 cm−1, 1H NMR data in deuterated methanol of δ ppm:
- 4.73 (1H, d), 2.10 (1H, dd), 2.05 (1H, ddd), 2.88 (1H, ddd), 1.25 (1H, ddd), 2.43 (1H, ddd), 1.62 (1H), 1.85 (1H, dd), 2.55 (1H, m), 3.20 (1H, d, br), 4.30 (1H, d), 3.32 (1H, d), 2.75 (1H, q), 2.50 (1H, d), 4.55 (1H, dd), 1.60 (2H), 1.40 (1H, m), 1.52 (1H, m), 0.95 (3H, t), 1.35 (3H, s), 1.06 (3H, d), 1.03 (3H, d), and
- 13C NMR data in deuterated methanol of δ ppm:
- 73.8, 44.4, 167.9, 103.4, 19.3, 37.4, 85.0, 48.9, 37.3, 80.2, 73.0, 72.3, 52.7, 223.3, 44.4, 169.3, 34.6, 21.3, 14.4, 24.8, 13.7, 8.5.
A compound represented by the following formula II
- wherein the compound has a molecular weight of 392, a molecular formula of C22H32O6, an infrared absorption maximum at 3450 and 1672 cm−1, 1H NMR data in deuterated methanol of δ ppm:
- 4.61 (1H, d), 2.28 (1H, dd), 2.05 (1H, ddd), 2.91 (1H, ddd), 1.27 (1H, m), 2.59 (1H, m), 1.41 (1H, dd), 1.97 (1H, dd), 2.53 (1H, m), 3.68 (1H, dd), 4.54 (1H, dd), 6.74 (1H, d), 2.18 (1H, dd), 4.03 (1H, dd), 1.56 (1H, m), 1.59 (1H, m), 1.36 (1H, m), 1.43 (1H, d), 0.94 (3H, t), 1.37 (3H, s), 1.22 (3H, d), and
- 13C NMR data in deuterated methanol of δ ppm:
- 78.3, 43.5, 167.4, 104.0, 20.1, 33.8, 82.3, 50.4, 37.3, 84.8, 69.9, 150.7, 134.8, 205.2, 43.3, 168.3, 36.4, 20.7, 14.3, 24.9, 16.5.
Dependencies are inferred from the claim text.