# US 9,000,179 B2 · Inhibitors of proliferation and activation of signal transducer and activator of transcription (STATs)

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- Number: US 9,000,179 B2
- Document ID: US9000179B2
- Status: Granted
- Kind: B2
- Application number: 14/103,619
- Filed: 2013-12-11
- Published: 2014-08-14
- Granted: 2015-04-07
- Earliest claimed: 2008-07-08
- Assignees: Board of Regents, The University of Texas System
- Applicants: Board of Regents, The University of Texas System
- Inventors: Waldemar Priebe; Stanislaw Skora; Timothy Madden; Izabela Fokt; Charles Conrad
- Web page: https://patentgrep.com/patent/US9000179B2

## CPC

- C07D 213/57: Nitriles
- A61K 31/4402: only substituted in position 2, e.g. pheniramine, bisacodyl
- A61P 1/00: Drugs for disorders of the alimentary tract or the digestive system
- A61P 1/04: for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A61P 7/00: Drugs for disorders of the blood or the extracellular fluid
- A61P 9/00: Drugs for disorders of the cardiovascular system
- A61P 9/10: for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A61P 9/14: Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
- A61P 17/00: Drugs for dermatological disorders
- A61P 17/06: Antipsoriatics
- A61P 19/02: for joint disorders, e.g. arthritis, arthrosis
- A61P 25/00: Drugs for disorders of the nervous system
- A61P 29/00: Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P 35/00: Antineoplastic agents
- A61P 35/02: specific for leukemia
- A61P 37/04: Immunostimulants
- A61P 43/00: Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C07D 213/61: Halogen atoms or nitro radicals
- C07D: HETEROCYCLIC COMPOUNDS (macromolecular compounds C08)
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

Pyridine compounds effective in modulation STAT3 and/or STAT5 activation are provided that are useful in the prevention and treatment of proliferative disease and conditions including cancer, inflammation and proliferative skin disorders.

## Claims

### Claim 1

A method of treating cancer comprising administering to a patient in need thereof a therapeutically effective amount of a compound of the formula:
or a pharmaceutically acceptable salt of any of the above formulas, wherein the cancer is brain cancer, ovarian cancer, or pancreatic cancer.

### Claim 2 (depends on 1)

The method of claim 1, wherein the cancer is pancreatic cancer.

### Claim 3 (depends on 1)

The method of claim 1, wherein the cancer is brain cancer.

### Claim 4 (depends on 1)

The method of claim 1, wherein the cancer is ovarian cancer.

### Claim 5 (depends on 1)

The method of claim 1, wherein the compound is further defined as:
or a pharmaceutically acceptable salt thereof.

### Claim 6 (depends on 2)

The method of claim 2, wherein the compound is further defined as:
or a pharmaceutically acceptable salt thereof.