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US 9,000,173 B2Granted
Diamide compounds having muscarinic receptor antagonist and β2 adrenergic receptor agonist activity
AssigneeTheravance Respiratory Company, LLC
InventorsAdam D. Hughes, Yan Chen, John R. Jacobsen, Eric L. Stangeland, Rose Yen
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Abstract
This invention relates to a compound of formula I: or a pharmaceutically acceptable salt thereof. Such compounds possess both muscarinic receptor antagonist and β2 adrenergic receptor agonist activities. The invention also relates to pharmaceutical compositions comprising such compounds, processes and intermediates for preparing such compounds, and methods of using such compounds as bronchodilating agents to treat pulmonary disorders.
Claims5
A process for preparing a compound of the formula:
- or a pharmaceutically acceptable salt thereof, the process comprising deprotecting a compound of the formula:
- or a salt thereof;
- wherein Rx and Ry are independently selected from C1-4 alkyl, phenyl, and —C1-4 alkyl-(phenyl);
- and Rz is selected from C1-4 alkyl, phenyl, —C1-4 alkyl-(phenyl) and —O—(C1-4 alkyl).
1 more element
Dependencies are inferred from the claim text.