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US 9,000,165 B2Granted
Process for the preparation of anhydrous aripiprazole crystal form II
AssigneeDaewoong Pharmaceutical Co., Ltd.
InventorsSoo Jin Choi, Seong Soo Oh, Yong Suk Jin, Yong Tae Kim, Seung Jae Lee, Jeong Hyun Son
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Abstract
The present invention relates to a process for preparation of aripiprazole crystal form II by recrystallizing aripiprazole in a mixture of acetone and 1-methoxy-2-propanol or a single solvent of 1-methoxy-2-propanol. The simple process according to the present invention can produce aripiprazole crystal form II with high purity and high yield in a mass scale.
Claims7
A process for preparation of anhydrous aripiprazole crystal form II, which comprises the following steps:
- a) introducing aripiprazole crystal form III into a mixed solvent of acetone and 1-methoxy-2-propanol or a single solvent of 1-methoxy-2-propanol;
- b) dissolving aripiprazole crystal form III with heating and stirring;
- c) seeding a crystal of aripiprazole crystal form II;
- and
- d) isolating the desired aripiprazole crystal form II from the solution.
2 more elements
Dependencies are inferred from the claim text.