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US 9,000,162 B2Granted
5,8-difluoro-4-(2-(4-(heteroaryloxy)-phenyl)ethylamino)quinazolines and their use as agrochemicals
AssigneeDow AgroSciences LLC
InventorsWilliam K. Brewster, Carla J. R. Klittich, Chenglin Yao, Yuanming Zhu, Brent J. Rieder
Life of this patent
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Abstract
The present disclosure relates to compounds of Formula 1,5,8-difluoro-4-(2-(4-(heteroaryloxy)phenyl)ethylamino)quinazolines, and their use as agrochemicals and animal health products.
Claims11
A method of treatment for fungi, insects, and nematodes, comprising the step of:
- applying a compound according to Formula (I), to a plant or animal in need thereof, the compound of Formula I is as follows:
- wherein:
- R represents H, CH3, or a heterocycle selected from the group consisting of pyridinyl, pyrazinyl, pyrimidinyl, and pyridazinyl wherein the heterocycle may be optionally substituted with one or more groups selected from halo, lower alkyl, lower alkenyl, lower alkynyl, lower alkoxy, haloalkyl, haloalkoxy, NO2, CN, lower alkoxycarbonyl, and lower alkyl-SOq, when q is an integer from 0 to 2;
- Z represents a C—C single bond, CH2, NH, O, S, —CH2O—, or —OCH2—;
- m is 4;
- R1 are independently H, halo, lower alkyl, lower alkenyl, lower alkynyl, hydroxy, lower alkoxy, haloalkyl, haloalkoxy, NO2, CN, lower alkoxycarbonyl, mercapto, or lower alkylthio;
- Y is a C—C single bond, C(R7n)O or C(R7n);
- n is 2;
- R2 are independently H or lower alkyl;
- R7 are independently H or lower alkyl;
- X is NR3 or O, where R3 is selected from H, lower alkyl, lower alkyl-carbonyl, lower alkoxycarbonyl, hydroxy, lower alkoxy, lower alkyl-SOq, phenyl-SOq or substituted phenyl-SOq when q is an integer from 0 to 2;
- and
- R4 is H or F;
- with the proviso that when Y is C(R7n), R2n and one of R1 may be taken together to form a compound of formula (II)
11 more elements
A method of treatment for fungi, insects, and nematodes, comprising the step of:
- applying a compound according to Formula (I), to a plant or animal in need thereof, the compound of Formula I is as follows:
- wherein:
- R represents H, CH3, or a heterocycle selected from the group consisting of pyridinyl, pyrazinyl, pyrimidinyl, and pyridazinyl wherein the heterocycle may be optionally substituted with one or more groups selected from halo, lower alkyl, lower alkenyl, lower alkynyl, lower alkoxy, haloalkyl, haloalkoxy, NO2, CN, lower alkoxycarbonyl, and lower alkyl-SOq, when q is an integer from 0 to 2;
- Z represents a C—C single bond, CH2, NH, O, S, —CH2O—, or —OCH2—;
- m is 4;
- R1 are independently H, halo, lower alkyl, lower alkenyl, lower alkynyl, hydroxy, lower alkoxy, haloalkyl, haloalkoxy, NO2, CN, lower alkoxycarbonyl, mercapto, or lower alkylthio;
- Y is a C—C single bond, C(R7n)O or C(R7n);
- n is 2;
- R2 are independently H or lower alkyl;
- R7 are independently H or lower alkyl;
- X is NR3 or O, where R3 is selected from H, lower alkyl, lower alkyl-carbonyl, lower alkoxycarbonyl, hydroxy, lower alkoxy, lower alkyl-SOq, phenyl-SOq or substituted phenyl-SOq when q is an integer from 0 to 2;
- and
- R4 is H or F;
- with the proviso that when Y is C(R7n), R2n, and one of R1 may be taken together to form a compound of formula (II)
- wherein the compound of Formula I is applied to at least one fungi, insect, or nematode selected from the group consisting of:
- Psuedoperonospora cubensis, Magnaporthe grisea, Puccinia recondite tritici, Septoria tritici, Spodoptera exigua, Aedes aegypti, Drosophila melanogaster, Leptinotarsa decemlineata, and Caenorhabditis elegans, optionally applied along with one additional agriculturally active compound selected from the group consisting of:
- carbanilate fungicides, pyrazole fungicides, methoxycarbanilate strobilurin fungicides, and conazole fungicides.
14 more elements
Dependencies are inferred from the claim text.