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US 9,000,155 B2Granted
Cyclic triazo sodium channel blockers
AssigneeUniversity of Greenwich
InventorsMichael Leach, Karl Franzmann, Dieter Riddall, Laurence Harbige
Life of this patent
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Abstract
The present invention relates to triazine compounds having sodium channel blocking properties, and to use of the compounds for preparation of medicaments for treatment of associated disorders. The compounds are of formula I: in which R1 is a halo-alkyl group and A is an optionally substituted aromatic heterocyclic or carbocyclic ring system, or a pharmaceutically acceptable salt or solvate thereof.
Claims21
A compound according to formula (I):
- or a pharmaceutically acceptable salt or solvate thereof,
- wherein
- i) A is 2,3-dichlorophenyl and R1 is —CH2CCl3, —CH2CF2CF3, or —CH2CF2CHF2;
- ii) A is 2,3,5-trichlorophenyl and R1 is —CH2CCl3, —CH2CHCl2, or CH2CBr3;
- iii) A is 3,5,-bistrifluoromethylphenyl and R1 is —CH2CCl3, —CH2CHCl2, or CH2CBr3;
- iv) A is bisphenyl methyl and R1 is —CH2CCl3, —CH2CHCl2, or CH2CBr3;
- or
- v) A is 2-(3,4,5)-trichloro-bis-phenyl and R1 is —CH2CCl3, —CH2CHCl2, or CH2CBr3.
5 more elements
A compound according to formula (II):
- or a pharmaceutically acceptable salt or solvate thereof,
- wherein R1 is a halo-alkyl group;
- W is sulphur, oxygen, or nitrogen;
- n is 1, 2 or 3;
- and R2 is one or more substituent groups.
2 more elements
Dependencies are inferred from the claim text.