Back to results
US 9,000,151 B2Granted
Sweet flavor modifier
AssigneeSenomyx, Inc.
InventorsSara L. Adamski-Werner, Vincent Darmohusodo, Catherine Tachdjian, Donald S. Karanewsky
Life of this patent
Estimating the term…
Abstract
The present invention includes compounds having structural formula (I): or salts or solvates thereof. These compounds are useful as sweet flavor modifiers. The present invention also includes compositions comprising the present compounds and methods of enhancing the sweet taste of compositions.
Claims13
A compound having structural Formula (I):
- or a salt or solvate thereof;
- wherein
- R1 and R2 are independently C1 to C4 alkyl;
- or alternatively, R1 and R2, together with the carbon atom to which they are attached, form a C3 to C7 cycloalkyl;
- R is hydrogen or C1 to C6 alkyl;
- and
- Het is heteroaryl or substituted heteroaryl, wherein the substituents are selected from the group consisting of —Ra, halo, —O−, ═O, —ORb, —SRb, —S−, ═S, —NRcRc, ═NRb, ═N—ORb, trihalomethyl, —CF3, —CN, —OCN, —SCN, —S(O)2Rb, —S(O)2NRb, —S(O)2O−, —S(O)2ORb, —OS(O)2Rb, —OS(O)2O−, —OS(O)2ORb, —C(O)Rb, —C(S)Rb, —C(NRb)Rb, —C(O)O−, —C(O)ORb, —C(S)ORb, —C(O)NRcRc, —C(NRb)NRcRc, —OC(O)Rb, —OC(S)Rb, —OC(O)O−, —OC(O)ORb, —OC(S)ORb, —NRbC(O)Rb, —NRbC(S)Rb, —NRbC(O)O−, —NRbC(O)ORb, —NRbC(S)ORb, —NRbC(O)NRcRc, —NRbC(NRb)Rb and —NRbC(NRb)NRcRc, where Ra is selected from the group consisting of alkyl, cycloalkyl, heteroalkyl, cycloheteroalkyl, aryl, arylalkyl, heteroaryl and heteroarylalkyl;
- each Rb is independently hydrogen or Ra;
- and each Rc is independently Rb or alternatively, the two Rcs may be taken together with the nitrogen atom to which they are bonded form a 4-, 5-, 6- or 7-membered cycloheteroalkyl which may optionally include from 1 to 4 of the same or different additional heteroatoms selected from the group consisting of O, N and S.
6 more elements
Dependencies are inferred from the claim text.