Nicotyl riboside compositions and methods of use
AssigneeCornell University
InventorsAnthony A. Sauve, Tianle Yang Redanz
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Abstract
The invention relates to compositions of nicotinoyl ribosides and nicotinamide riboside derivatives and their methods of use. In some embodiments, the invention relates to methods of making nicotinoyl ribosides. In some embodiments, the invention relates to pharmaceutical compositions and nutritional supplements containing a nicotinoyl riboside. In further embodiments, the invention relates to methods of using nicotinoyl ribosides and nicotinamide riboside derivatives that promote the increase of intracellular levels of nicotinamide adenine dinucleotide (NAD+) in cells and tissues for improving cell and tissue survival.
Claims30
A compound having the formula:
- and salt complexes thereof wherein R is selected from the group consisting of alkylamino, substituted alkylamino, dialkylamino, substituted dialkylamino, alkyloxy, substituted alkyloxy, aryloxy, substituted aryloxy, hydroxylamino, substituted hydroxylamino, O-alkyloxyamino, substituted O-alkyloxyamino, aminooxy, substituted aminoxy, N-alkylaminooxy, substituted N-alkylaminoxy, hydrazino, substituted hydrazino, alkylhydrazino, and substituted alkylhydrazino.
A compound having the following formula:
- and salt complexes thereof wherein,
- R1 is alkyloxy, substituted alkyloxy, aryloxy, substituted aryloxy, arylthio, substituted arylthio, alkylthio, substituted alkylthio, aminooxy, substituted aminoxy, N-alkylaminooxy, and substituted N-alkylaminooxy;
- and
- R2, R3, and R4 are the same or different and, at each occurrence, independently unsubstituted —C(═O)alkyl or substituted —C(═O)alkyl.
A compound having the following formula:
- and salt complexes thereof, wherein
- R1 is alkylamino, dialkylamino, substituted dialkylamino, hydrazine, substituted hydrazino, N-alkylaminohydrazino, hydroxylamino, substituted hydroxylamino, O-alkyloxyamino, substituted O-alkyloxyamino, —NHCH2CH2OH, —NHCH2CH═CH2, or —NHCH2CH2NH2;
- R2, R3, and R4 are the same or different and, at each occurrence, independently unsubstituted —C(═O)alkyl or substituted —C(═O)alkyl.
A compound having the following formula:
- and salt complexes thereof wherein
- R1 is alkylamino, substituted alkylamino, dialkylamino, substituted dialkylamino, hydroxylamino, O-alkyloxyamino, substituted O-alkyloxyamino, hydrazino, alkylhydrazino, or substituted alkylhydrazino, and
- R2 is unsubstituted —C(═O)alkyl, substituted —C(═O)alkyl, unsubstituted —C(═O)aryl, or substituted —C(═O)aryl.
A compound having the following formula:
- and salt complexes thereof wherein,
- R1 is substituted alkyloxy, aryloxy, substituted aryloxy, arylthio, substituted arylthio, alkylthio, substituted alkylthio, aminooxy, substituted aminoxy, N-alkylaminooxy, and substituted N-alkylaminooxy;
- and
- R2, R3, and R4 are the same or different and, at each occurrence, independently unsubstituted —C(═O)aryl or substituted —C(═O)aryl.
A compound having the following formula:
- and salt complexes thereof, wherein
- R1 is alkylamino, substituted dialkylamino, hydrazine, substituted hydrazino, N-alkylaminohydrazino, hydroxylamino, substituted hydroxylamino, O-alkyloxyamino, substituted O-alkyloxyamino, —NHCH2CH2OH, —NHCH2CH═CH2, or —NHCH2CH2NH2;
- R2, R3, and R4 are the same or different and, at each occurrence, independently unsubstituted —C(═O)aryl or substituted —C(═O)aryl.
A compound having the following formula:
- and salt complexes thereof, wherein
- R1 is amino and
- R2 is unsubstituted —C(═O)alkyl or substituted —C(═O)aryl.
Dependencies are inferred from the claim text.