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AssigneeAlnylam Pharmaceuticals, Inc.
InventorsAntonin de Fougerolles, Andrew Sprague, Jens Harborth, Maria Gabriela Belvisi, Mark Andrew Birrell, Elizabeth Louise Hardaker, Matthew Copeland Catley
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The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of the IKK-B gene, comprising an antisense strand having a nucleotide sequence which is less that 30 nucleotides in length, generally 19-25 nucleotides in length, and which is substantially complementary to at least a part of the IKK-B gene. The invention also relates to a pharmaceutical composition comprising the dsRNA together with a pharmaceutically acceptable carrier; methods for treating diseases caused by the expression or activation of the IKK-B gene using the pharmaceutical composition; and methods for inhibiting the expression of the IKK-B gene in a cell.
A double-stranded ribonucleic acid (dsRNA) compound, comprising an antisense strand and a sense strand that are separate and each equal to or less than 30 nucleotides in length, wherein the compound is targeted to the target sequence of AL-DP-4440 (SEQ ID NO:25 and SEQ ID NO:26) within a nucleic acid molecule encoding IKK-B, and wherein the compound specifically hybridizes with the nucleic acid molecule so that expression of IKK-B is inhibited by at least 40%.
Dependencies are inferred from the claim text.